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Mg alloy surface immobilised with caerin peptides acquires enhanced antibacterial ability and improved corrosion resistance377.97 kB
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Preprint
Mg alloy surface immobilised with caerin peptides acquires enhanced antibacterial ability and improved corrosion resistance
Research Square, Vol.14 October 2020
Research Square Company
2020
Abstract
Magnesium (Mg) has mechanical properties similar to human bones and Mg alloy is considered ideal medical implant material. However, the high velocity of degradation inside the human inner environment severely hampers the usage of Mg alloys. In this study, caerin peptide 1.9 (F3) and a modified sequence of caerin 1.1 (F1) with anti-bacterial activity, were covalently immobilised on the surface of Mg alloys by plasma chemical click reaction. The in vitro antibacterial activity and corrosion resistance of these caerin peptide-immobilised Mg alloys were investigated in Dulbecco's Modified Eagle Medium (DMEM) solution. Un-immobilised Mg alloy sample, blank drug-sensitive tablet (BASD) and a commonly used antibiotics Tazocin were used for comparison. Results showed that peptide immobilised Mg samples showed significant improved corrosion resistance and prolonged antibacterial effect compared to non-immobilised Mg alloy and free caerin peptides. Furthermore, annealing or extruding treatment of Mg alloys improved the behaviours of corrosion resistance and antibacterial property. These results indicate that coating Mg alloy with caerin peptides improves the corrosion resistance in vitro and increases the alloy’s antibacterial ability. The mechanism underlying the prolonged antibacterial effect for annealed Mg alloys immobilised with the peptides (especially F3) remains unclear, which worth further experimental and theoretical investigation.
Details
- Title
- Mg alloy surface immobilised with caerin peptides acquires enhanced antibacterial ability and improved corrosion resistance
- Authors
- Tianfang Wang (Author) - University of the Sunshine Coast, Queensland, School of Science and Engineering - LegacyGuoying Ni (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyTsuyoshi Furushima (Author) - The University of TokyoHui Diao (Author) - The University of QueenslandPing Zhang (Author) - First People's Hospital of FoshanShu Chen (Author) - First People's Hospital of FoshanConor Fogarty (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyZhengyi Jiang (Author) - University of WollongongXiao Song Liu (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyHejie Li (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
- Publication details
- Research Square, Vol.14 October 2020
- Publisher
- Research Square Company
- Date published
- 2020
- DOI
- 10.21203/rs.3.rs-92270/v1
- ISSN
- 2693-5015
- Copyright note
- Copyright (C) 2020 The authors. This work is licensed under a CC BY 4.0 License. (https://creativecommons.org/licenses/by/4.0/)
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99482292402621
- Output Type
- Preprint
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