Journal article
Mg alloy surface immobilised with caerin peptides acquires enhanced antibacterial ability and putatively improved corrosion resistance
Materials Science & Engineering: C, Vol.121, pp.1-14
2021
PMID: 33579462
Abstract
Magnesium (Mg) has mechanical properties similar to human bones and Mg alloy is considered ideal medical implant material. However, the high velocity of degradation inside the human inner environment severely hampers the usage of Mg alloys. In this study, caerin peptide 1.9 (F3) and a modified sequence of caerin 1.1 (F1) with anti-bacterial activity, were covalently immobilised on the surface of Mg alloys by plasma chemical click reaction. The in vitro antibacterial activity and corrosion resistance of these caerin peptide-immobilised Mg alloys were investigated in Dulbecco's Modified Eagle Medium (DMEM) solution. Un-immobilised Mg alloy sample, blank drug-sensitive tablet (BASD) and a commonly used antibiotics Tazocin were used for comparison. Results showed that peptide immobilised Mg samples showed observable improved corrosion resistance and prolonged antibacterial effect compared to non-immobilised Mg alloy and free caerin peptides. These results indicate that coating Mg alloy with caerin peptides obviously increases the alloy’s antibacterial ability and putatively improves the corrosion resistance in vitro. The mechanism underlying the prolonged antibacterial effect for annealed Mg alloys immobilised with the peptides (especially F3) remains unclear, which worth further experimental and theoretical investigation.
•Caerin peptides were immobilised on Mg’s surface by plasma chemical click reaction•Peptide coated Mg got better corrosion resistance, prolonged antibacterial effect•Peptide coated annealed Mg showed a better antibacterial behavior than antibiotics•Peptide immobilised annealed Mg showed a long-lasting antibacterial behavior•Different treatments showed the different effects on Mg’s corrosion resistance
Details
- Title
- Mg alloy surface immobilised with caerin peptides acquires enhanced antibacterial ability and putatively improved corrosion resistance
- Authors
- Tianfang Wang (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyGuoying Ni (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyTsuyoshi Furushima (Author) - The University of TokyoHui Diao (Author) - The University of QueenslandPingping Zhang (Author) - First People's Hospital of FoshanShu Chen (Author) - First People's Hospital of FoshanConor E Fogarty (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyZhengyi Jiang (Author) - University of WollongongXiaosong Liu (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyHejie Li (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
- Publication details
- Materials Science & Engineering: C, Vol.121, pp.1-14
- Publisher
- Elsevier BV
- Date published
- 2021
- DOI
- 10.1016/j.msec.2020.111819
- ISSN
- 1873-0191
- PMID
- 33579462
- Organisation Unit
- School of Science and Engineering - Legacy; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99498106802621
- Output Type
- Journal article
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- Domestic collaboration
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- Web Of Science research areas
- Materials Science, Biomaterials
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