Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group

Laura K M Han; Richard Dinga; Tim Hahn; Christopher Ching; Lisa Eyler; Lyubomir Aftanas; Moji Aghajani; Andre Aleman; Bernhard Baune; Klaus Berger; Ivan Brak; Geraldo Busatto Filho; Angela Carballedo; Colm Connolly; Baptiste Couvy-Duchesne; Kathryn Cullen; Udo Dannlowski; Christopher Davey; Danai Dima; Fabio Duran; Verena Enneking; Elena Filimonova; Stefan Frenzel; Thomas Frodl; Cynthia Fu; Beata Godlewska; I Gotlib; H Grabe; N Groenewold; D Grotegerd; O Gruber; G Hall; B Harrison; S Hatton; M Hermesdorf; I Hickie; T Ho; N Hosten; A Jansen; C Kahler; T Kircher; B Klimes-Dougan; B Kramer; A Krug; Jim Lagopoulos; R Leenings; F MacMaster; G MacQueen; A McIntosh; Q McLellan; K McMahon; S Medland; B Mueller; B Mwangi; E Osipov; M Portella; E Pozzi; L Reneman; J Repple; P Rosa; M Sacchet; P Saemann; K Schnell; A Schrantee; E Simulionyte; J Soares; J Sommer; D Stein; O Steinstrater; L Strike; S Thomopoulos; M-J van Tol; I Veer; R Vermeiren; H Walter; N van der Wee; S van der Werff; H Whalley; N Winter; K Wittfeld; M Wright; M-J Wu; H Volzke; T Yang; V Zannias; G de Zubicaray; G Zunta-Soares; C Abe; M Alda; O Andreassen; E Boen; C Bonnin; E Canales-Rodriguez; D Cannon; X Caseras; T Chaim-Avancini; T Elvsashagen; P Favre; S Foley; J Fullerton; J Goikolea; B Haarman; T Hajek; C Henry; J Houenou; F Howells; M Ingvar; R Kuplicki; B Lafer; M Landen; R Machado-Viera; U Malt; C McDonald; P Mitchell; L Nabulsi; M Otaduy; B Overs; M Polosan; E Pomarol-Clotet; J Radua; M Rive; G Roberts; H Ruhe; R Salvador; S Sarro; T Satterthwaite; J Savitz; A Schene; P Schofeld; M Serpa; K Sim; M Soeiro-de-Souza; A Sutherland; H Temmingh; G Timmons; A Uhlmann; E Vieta; D Wolf; M Zanett; N Jahanshad; Paul Thompson; D Veltman; Brenda Penninx; A Marquand; J Cole; L Schmaal

doi:10.1101/560623

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Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group

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Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group

Laura K M Han, Richard Dinga, Tim Hahn, Christopher Ching, Lisa Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard Baune, Klaus Berger, …

bioRxiv

Cold Spring Harbor Laboratory Press

2019

DOI: https://doi.org/10.1101/560623

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Brain aging in major depressive disorder: results from the ENIGMA major depressi...

Abstract

Public Health and Health Services

Psychology

Background: Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in MDD patients, and whether this process is associated with clinical characteristics in a large multi-center international dataset. Methods: We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 29 samples worldwide. Normative brain aging was estimated by predicting chronological age (10-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 1,147 male and 1,386 female controls from the ENIGMA MDD working group. The learned model parameters were applied to 1,089 male controls and 1,167 depressed males, and 1,326 female controls and 2,044 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted brain age and chronological age was calculated to indicate brain predicted age difference (brain-PAD). Findings: On average, MDD patients showed a higher brain-PAD of +0.90 (SE 0.21) years (Cohen's d=0.12, 95% CI 0.06-0.17) compared to controls. Relative to controls, first-episode and currently depressed patients showed higher brain-PAD (+1.2 [0.3] years), and the largest effect was observed in those with late-onset depression (+1.7 [0.7] years). In addition, higher brain-PAD was associated with higher self-reported depressive symptomatology (b=0.05, p=0.004). Interpretation: This highly powered collaborative effort showed subtle patterns of abnormal structural brain aging in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the predictive value of these brain-PAD estimates.

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Title: Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group
Authors: Laura K M Han (Author)
Richard Dinga (Author)
Tim Hahn (Author)
Christopher Ching (Author)
Lisa Eyler (Author)
Lyubomir Aftanas (Author)
Moji Aghajani (Author)
Andre Aleman (Author)
Bernhard Baune (Author)
Klaus Berger (Author)
Ivan Brak (Author)
Geraldo Busatto Filho (Author)
Angela Carballedo (Author)
Colm Connolly (Author)
Baptiste Couvy-Duchesne (Author)
Kathryn Cullen (Author)
Udo Dannlowski (Author)
Christopher Davey (Author)
Danai Dima (Author)
Fabio Duran (Author)
Verena Enneking (Author)
Elena Filimonova (Author)
Stefan Frenzel (Author)
Thomas Frodl (Author)
Cynthia Fu (Author)
Beata Godlewska (Author)
I Gotlib (Author)
H Grabe (Author)
N Groenewold (Author)
D Grotegerd (Author)
O Gruber (Author)
G Hall (Author)
B Harrison (Author)
S Hatton (Author)
M Hermesdorf (Author)
I Hickie (Author)
T Ho (Author)
N Hosten (Author)
A Jansen (Author)
C Kahler (Author)
T Kircher (Author)
B Klimes-Dougan (Author)
B Kramer (Author)
A Krug (Author)
Jim Lagopoulos (Author) - University of the Sunshine Coast
R Leenings (Author)
F MacMaster (Author)
G MacQueen (Author)
A McIntosh (Author)
Q McLellan (Author)
K McMahon (Author)
S Medland (Author)
B Mueller (Author)
B Mwangi (Author)
E Osipov (Author)
M Portella (Author)
E Pozzi (Author)
L Reneman (Author)
J Repple (Author)
P Rosa (Author)
M Sacchet (Author)
P Saemann (Author)
K Schnell (Author)
A Schrantee (Author)
E Simulionyte (Author)
J Soares (Author)
J Sommer (Author)
D Stein (Author)
O Steinstrater (Author)
L Strike (Author)
S Thomopoulos (Author)
M-J van Tol (Author)
I Veer (Author)
R Vermeiren (Author)
H Walter (Author)
N van der Wee (Author)
S van der Werff (Author)
H Whalley (Author)
N Winter (Author)
K Wittfeld (Author)
M Wright (Author)
M-J Wu (Author)
H Volzke (Author)
T Yang (Author)
V Zannias (Author)
G de Zubicaray (Author)
G Zunta-Soares (Author)
C Abe (Author)
M Alda (Author)
O Andreassen (Author)
E Boen (Author)
C Bonnin (Author)
E Canales-Rodriguez (Author)
D Cannon (Author)
X Caseras (Author)
T Chaim-Avancini (Author)
T Elvsashagen (Author)
P Favre (Author)
S Foley (Author) - Cardiff University
J Fullerton (Author)
J Goikolea (Author)
B Haarman (Author)
T Hajek (Author)
C Henry (Author)
J Houenou (Author)
F Howells (Author)
M Ingvar (Author)
R Kuplicki (Author)
B Lafer (Author)
M Landen (Author)
R Machado-Viera (Author)
U Malt (Author)
C McDonald (Author)
P Mitchell (Author)
L Nabulsi (Author)
M Otaduy (Author)
B Overs (Author)
M Polosan (Author)
E Pomarol-Clotet (Author)
J Radua (Author)
M Rive (Author)
G Roberts (Author)
H Ruhe (Author)
R Salvador (Author)
S Sarro (Author)
T Satterthwaite (Author)
J Savitz (Author)
A Schene (Author)
P Schofeld (Author)
M Serpa (Author)
K Sim (Author)
M Soeiro-de-Souza (Author)
A Sutherland (Author)
H Temmingh (Author)
G Timmons (Author)
A Uhlmann (Author)
E Vieta (Author)
D Wolf (Author)
M Zanett (Author)
N Jahanshad (Author)
Paul Thompson (Author)
D Veltman (Author)
Brenda Penninx (Author)
A Marquand (Author)
J Cole (Author)
L Schmaal (Author)
Publication details: bioRxiv
Publisher: Cold Spring Harbor Laboratory Press
Date published: 2019
DOI: 10.1101/560623
ISSN: 2692-8205
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450661902621
Output Type: Preprint

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