Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Laura K M Han; Richard Dinga; Tim Hahn; Christopher R K Ching; Lisa T Eyler; Lyubomir Aftanas; Moji Aghajani; André Aleman; Bernhard T Baune; Klaus Berger; Ivan Brak; Geraldo Busatto Filho; Angela Carballedo; Colm G Connolly; Baptiste Couvy-Duchesne; Kathryn R Cullen; Udo Dannlowski; Christopher G Davey; Danai Dima; Fabio L S Duran; Verena Enneking; Elena Filimonova; Stefan Frenzel; Thomas Frodl; Cynthia H Y Fu; Beata R Godlewska; Ian H Gotlib; Hans J Grabe; Nynke A Groenewold; Dominik Grotegerd; Oliver Gruber; Geoffrey B Hall; Ben J Harrison; Sean N Hatton; Marco Hermesdorf; Ian B Hickie; Tiffany C Ho; Norbert Hosten; Andreas Jansen; Claas Kähler; Tilo Kircher; Bonnie Klimes-Dougan; Bernd Krämer; Axel Krug; Jim Lagopoulos; Ramona Leenings; Frank P MacMaster; Glenda MacQueen; Andrew McIntosh; Quinn McLellan; Katie L McMahon; Sarah E Medland; Bryon A Mueller; Benson Mwangi; Evgeny Osipov; Maria J Portella; Elena Pozzi; Liesbeth Reneman; Jonathan Repple; Pedro G P Rosa; Matthew D Sacchet; Philipp G Sämann; Knut Schnell; Anouk Schrantee; Egle Simulionyte; Jair C Soares; Jens Sommer; Dan J Stein; Olaf Steinsträter; Lachlan T Strike; Sophia I Thomopoulos; Marie-José van Tol; Ilya M Veer; Robert R J M Vermeiren; Henrik Walter; Nic J A van der Wee; Steven J A van der Werff; Heather Whalley; Nils R Winter; Katharina Wittfeld; Margaret J Wright; Mon-Ju Wu; Henry Völzke; Tony T Yang; Vasileios Zannias; Greig I de Zubicaray; Giovana B Zunta-Soares; Christoph Abé; Martin Alda; Ole A Andreassen; Erlend Bøen; Caterina M Bonnin; Erick J Canales-Rodriguez; Dara Cannon; Xavier Caseras; Tiffany M Chaim-Avancini; Torbjørn Elvsåshagen; Pauline Favre; Sonya F Foley; Janice M Fullerton; Jose M Goikolea; Bartholomeus C M Haarman; Tomas Hajek; Chantal Henry; Josselin Houenou; Fleur M Howells; Martin Ingvar; Rayus Kuplicki; Beny Lafer; Mikael Landén; Rodrigo Machado-Vieira; Ulrik F Malt; Colm McDonald; Philip B Mitchell; Leila Nabulsi; Maria Concepcion Garcia Otaduy; Bronwyn J Overs; Mircea Polosan; Edith Pomarol-Clotet; Joaquim Radua; Maria M Rive; Gloria Roberts; Henricus G Ruhe; Raymond Salvador; Salvador Sarró; Theodore D Satterthwaite; Jonathan Savitz; Aart H Schene; Peter R Schofield; Mauricio H Serpa; Kang Sim; Marcio Gerhardt Soeiro-de-Souza; Ashley N Sutherland; Henk S Temmingh; Garrett M Timmons; Anne Uhlmann; Eduard Vieta; Daniel H Wolf; Marcus V Zanetti; Neda Jahanshad; Paul M Thompson; Dick J Veltman; Brenda W J H Penninx; Andre F Marquand; James H Cole; Lianne Schmaal

doi:10.1038/s41380-020-0754-0

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Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

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Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Laura K M Han, Richard Dinga, Tim Hahn, Christopher R K Ching, Lisa T Eyler, Lyubomir Aftanas, Moji Aghajani, André Aleman, Bernhard T Baune, Klaus Berger, …

Molecular Psychiatry, Vol.26, pp.5124-5139

2021

DOI: https://doi.org/10.1038/s41380-020-0754-0

PMCID: PMC8589647

PMID: 32424236

Appears in Thompson Institute Research Collection

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Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressi...

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depression

neuroscience

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Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.

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Title: Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
Authors: Laura K M Han (Corresponding Author) - Vrije Universiteit Brussel
Richard Dinga (Author) - Radboud University Medical Center
Tim Hahn (Author) - University of Münster
Christopher R K Ching (Author) - University of Southern California
Lisa T Eyler (Author) - University of San Diego
Lyubomir Aftanas (Author) - Novosibirsk State University
Moji Aghajani (Author) - Vrije Universiteit Brussel
André Aleman (Author) - University of Groningen
Bernhard T Baune (Author) - University of Münster
Klaus Berger (Author) - University of Münster
Ivan Brak (Author) - Novosibirsk State University
Geraldo Busatto Filho (Author) - University of Sao Paulo
Angela Carballedo (Author) - North Dublin Mental Health Services, Dublin, Ireland
Colm G Connolly (Author) - Florida State University
Baptiste Couvy-Duchesne (Author) - The University of Queensland
Kathryn R Cullen (Author) - University of Minnesota
Udo Dannlowski (Author) - University of Münster
Christopher G Davey (Author) - The University of Melbourne
Danai Dima (Author) - University of London
Fabio L S Duran (Author) - University of Sao Paulo
Verena Enneking (Author) - University of Münster
Elena Filimonova (Author) - Institute of Physiology and Basic Medicine
Stefan Frenzel (Author) - Universität Greifswald
Thomas Frodl (Author) - Trinity College Dublin
Cynthia H Y Fu (Author) - University of East London
Beata R Godlewska (Author) - University of Oxford
Ian H Gotlib (Author) - Stanford University
Hans J Grabe (Author) - German Center for Neurodegenerative Diseases
Nynke A Groenewold (Author) - University of Cape Town
Dominik Grotegerd (Author) - University of Münster
Oliver Gruber (Author) - Heidelberg University
Geoffrey B Hall (Author) - Princess Alexandra Hospital
Ben J Harrison (Author) - The University of Melbourne
Sean N Hatton (Author) - University of California San Diego
Marco Hermesdorf (Author) - University of Münster
Ian B Hickie (Author) - The University of Sydney
Tiffany C Ho (Author) - Stanford University
Norbert Hosten (Author) - Universitätsmedizin Greifswald
Andreas Jansen (Author) - Philipps University of Marburg
Claas Kähler (Author) - University of Münster
Tilo Kircher (Author) - Philipps University of Marburg
Bonnie Klimes-Dougan (Author) - University of Minnesota
Bernd Krämer (Author) - Heidelberg University
Axel Krug (Author) - University of Bonn
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Ramona Leenings (Author) - University of Münster
Frank P MacMaster (Author) - University of Calgary
Glenda MacQueen (Author) - University of Calgary
Andrew McIntosh (Author) - University of Edinburgh
Quinn McLellan (Author) - University of Alberta
Katie L McMahon (Author) - Queensland University of Technology
Sarah E Medland (Author) - QIMR Berghofer Medical Research Institute
Bryon A Mueller (Author) - University of Minnesota
Benson Mwangi (Author) - The University of Texas Health Science Center at Houston
Evgeny Osipov (Author) - Novosibirsk State University
Maria J Portella (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Elena Pozzi (Author) - The University of Melbourne
Liesbeth Reneman (Author) - University of Amsterdam
Jonathan Repple (Author) - University of Münster
Pedro G P Rosa (Author) - University of Sao Paulo
Matthew D Sacchet (Author) - Harvard Medical School
Philipp G Sämann (Author) - Max Planck Institute of Psychiatry
Knut Schnell (Author) - Asklepios Fachklinikum Brandenburg
Anouk Schrantee (Author) - University of Amsterdam
Egle Simulionyte (Author) - McMaster University
Jair C Soares (Author) - The University of Texas Health Science Center at Houston
Jens Sommer (Author) - University of Minnesota
Dan J Stein (Author) - University of Cape Town
Olaf Steinsträter (Author) - Universität Greifswald
Lachlan T Strike (Author) - The University of Queensland
Sophia I Thomopoulos (Author) - University of Southern California
Marie-José van Tol (Author) - University Medical Center Groningen
Ilya M Veer (Author) - Berlin Institute of Health at Charité - Universitätsmedizin Berlin
Robert R J M Vermeiren (Author) - Leiden University
Henrik Walter (Author) - Humboldt-Universität zu Berlin
Nic J A van der Wee (Author) - Leiden University Medical Center
Steven J A van der Werff (Author) - Leiden University Medical Center
Heather Whalley (Author) - University of Edinburgh
Nils R Winter (Author) - University of Münster
Katharina Wittfeld (Author) - Universität Greifswald
Margaret J Wright (Author) - The University of Queensland
Mon-Ju Wu (Author) - The University of Texas Health Science Center at Houston
Henry Völzke (Author) - Universität Greifswald
Tony T Yang (Author) - University of California, San Francisco
Vasileios Zannias (Author) - University of Edinburgh
Greig I de Zubicaray (Author) - Queensland University of Technology
Giovana B Zunta-Soares (Author) - The University of Texas Health Science Center at Houston
Christoph Abé (Author) - Karolinska Institutet
Martin Alda (Author) - Dalhousie University
Ole A Andreassen (Author) - Oslo University Hospital
Erlend Bøen (Author) - Oslo University Hospital
Caterina M Bonnin (Author) - Universitat de Barcelona
Erick J Canales-Rodriguez (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Dara Cannon (Author) - Ollscoil na Gaillimhe – University of Galway
Xavier Caseras (Author) - Cardiff University
Tiffany M Chaim-Avancini (Author) - University of Sao Paulo
Torbjørn Elvsåshagen (Author) - Oslo University Hospital
Pauline Favre (Author) - Hôpitaux Universitaires Henri Mondor
Sonya F Foley (Author) - Cardiff University
Janice M Fullerton (Author) - UNSW Australia
Jose M Goikolea (Author) - Universitat de Barcelona
Bartholomeus C M Haarman (Author) - University of Groningen
Tomas Hajek (Author) - Dalhousie University
Chantal Henry (Author) - South Eastern Sydney Local Health District
Josselin Houenou (Author) - Hôpitaux Universitaires Henri Mondor
Fleur M Howells (Author) - University of Cape Town
Martin Ingvar (Author) - Karolinska Institutet
Rayus Kuplicki (Author) - Laureate Institute for Brain Research
Beny Lafer (Author) - University of Sao Paulo
Mikael Landén (Author) - Karolinska Institutet
Rodrigo Machado-Vieira (Author) - University of Sao Paulo
Ulrik F Malt (Author) - Oslo University Hospital
Colm McDonald (Author) - Ollscoil na Gaillimhe – University of Galway
Philip B Mitchell (Author) - Prince of Wales Hospital
Leila Nabulsi (Author) - Ollscoil na Gaillimhe – University of Galway
Maria Concepcion Garcia Otaduy (Author) - University of Sao Paulo
Bronwyn J Overs (Author) - Neuroscience Research Australia
Mircea Polosan (Author) - Institut polytechnique de Grenoble
Edith Pomarol-Clotet (Author) - Fidmag Sisters Hospitallers
Joaquim Radua (Author) - Universitat de Barcelona
Maria M Rive (Author) - University of Amsterdam
Gloria Roberts (Author) - Prince of Wales Hospital
Henricus G Ruhe (Author) - Radboud University Medical Center
Raymond Salvador (Author) - Fidmag Sisters Hospitallers
Salvador Sarró (Author) - Fidmag Sisters Hospitallers
Theodore D Satterthwaite (Author) - University of Pennsylvania
Jonathan Savitz (Author) - University of Tulsa
Aart H Schene (Author) - Radboud University Medical Center
Peter R Schofield (Author) - UNSW Australia
Mauricio H Serpa (Author) - University of Sao Paulo
Kang Sim (Author) - National University of Singapore
Marcio Gerhardt Soeiro-de-Souza (Author) - University of Sao Paulo
Ashley N Sutherland (Author) - University of California San Diego
Henk S Temmingh (Author) - Valkenberg Hospital
Garrett M Timmons (Author) - University of California San Diego Medical Center
Anne Uhlmann (Author) - University of Cape Town
Eduard Vieta (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Daniel H Wolf (Author) - University of Pennsylvania
Marcus V Zanetti (Author) - University of Sao Paulo
Neda Jahanshad (Author) - University of Southern California
Paul M Thompson (Author) - University of Southern California
Dick J Veltman (Author) - Amsterdam UMC - Vrije Universiteit Amsterdam
Brenda W J H Penninx (Author) - Vrije Universiteit Brussel
Andre F Marquand (Author) - Radboud University Medical Center
James H Cole (Author) - University College London
Lianne Schmaal (Author) - The University of Melbourne
Publication details: Molecular Psychiatry, Vol.26, pp.5124-5139
Publisher: Nature Publishing Group
Date published: 2021
DOI: 10.1038/s41380-020-0754-0
ISSN: 1476-5578
PMID: 32424236; PMC8589647
Copyright note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Organisation Unit: Thompson Institute
Language: English
Record Identifier: 99489107102621
Output Type: Journal article

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