Journal article
Regional genetic diversity for NNV grouper viruses across the Indo-Asian region – implications for selecting virus resistance in farmed groupers
Scientific Reports, Vol.7, 10658
2017
Abstract
Grouper aquaculture around Asia is impacted by the nervous necrosis virus (NNV) and, in response, host resistance to this infection is being considered as a trait for selection. However efficient selection may be confounded if there are different genetic strains of NNV within and between regions and over years. This study uses statistical approaches and assessment of "characteristic attributes" (i.e. nucleotide positions that discriminate among strains) to assess whether published and new NNV RNA2 cds sequences show genetic differentiation over geography, host species and years. Rather clear evidence was found for regional strains of NNV. Interestingly, most of the geographic defining "characteristic attributes" were in codon position three, and not translated into differences for the protein capsid (i.e. they were synonymous variations), suggesting that while NNV strains were geographically isolated and had diverged in different regions for RNA sequences, selection had largely conserved the protein sequences among regions. The apparent selection constraint on the capsid protein may mitigate the risk that despite geographic subdivision, NNV strain variability will confound genetic selection for host resistance. The existence of regional Asian NNV strains may suggest that hatcheries are at risk from NNV not only from imported material but also from endemic reservoirs.
Details
- Title
- Regional genetic diversity for NNV grouper viruses across the Indo-Asian region – implications for selecting virus resistance in farmed groupers
- Authors
- Wayne R Knibb (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringGiang Luu (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringH K A Premachandra (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringMing-Wei Lu (Author) - National Taiwan Ocean University, TaiwanNguyen Hong Nguyen (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- Scientific Reports, Vol.7, 10658; 11
- Publisher
- Nature Publishing Group
- Date published
- 2017
- DOI
- 10.1038/s41598-017-11263-4
- ISSN
- 2045-2322
- Copyright note
- Copyright © Te Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article's Creative ommons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permittedby statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450352002621
- Output Type
- Journal article
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