Physical Activity Levels Are Low in Inoperable Lung Cancer: Exploratory Analyses from a Randomised Controlled Trial

Lara Edbrooke; Catherine L Granger; Ross Clark; Linda Denehy

doi:10.3390/jcm8091288

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Physical Activity Levels Are Low in Inoperable Lung Cancer: Exploratory Analyses from a Randomised Controlled Trial

Journal article

Open access

Peer reviewed

Physical Activity Levels Are Low in Inoperable Lung Cancer: Exploratory Analyses from a Randomised Controlled Trial

Lara Edbrooke, Catherine L Granger, Ross Clark and Linda Denehy

Journal of Clinical Medicine, Vol.8(9), 1288

2019

DOI: https://doi.org/10.3390/jcm8091288

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Abstract

Clinical Sciences

lung cancer

physical activity

exercise

quality of life

symptoms

Background: In inoperable lung cancer, evidence is limited regarding physical activity (PA) and associations with other outcomes. Aims: in the usual care (UC) group of an RCT to (1) explore whether baseline PA was associated with improved follow-up outcomes, (2) identify baseline variables associated with higher follow-up PA and in all RCT participants, to (3) analyse patterns of objectively measured PA, and (4) report on characteristics of those who were able to maintain or increase PA levels. Methods: exploratory analyses of an assessor-blinded RCT. Outcomes, assessed at baseline, nine weeks and six months, included PA (seven-days of accelerometry), six-minute walk distance (6MWD), muscle strength, symptoms, mood and health-related quality of life (HRQoL). Results: 92 participants were randomised, 80 completed baseline accelerometry (39 intervention group (IG), 41 UC), characteristics: mean (SD) age 63.0 (12.3) years, 56% male, 51% stage IV disease. Baseline PA: median (IQR) steps/day 2859.6 (2034.0-3849.2) IG versus 3195.2 (2161.2-4839.0) UC. Associations between baseline PA and six-month outcomes were significant for HRQoL and 6MWD. PA at six months was significantly associated with baseline age, 6MWD and quadriceps strength. Between-group change score (steps/day) mean differences (95% CI) at nine weeks (174.5 (-1504.7 to 1853.7), p = 0.84) and six months (574.0 (-1162.3 to 2310.3), p = 0.52). Conclusions: further research is required to determine patient subgroups deriving the greatest benefits from PA interventions.

Details

Title: Physical Activity Levels Are Low in Inoperable Lung Cancer: Exploratory Analyses from a Randomised Controlled Trial
Authors: Lara Edbrooke (Author) - University of Melbourne
Catherine L Granger (Author) - University of Melbourne
Ross Clark (Author) - University of the Sunshine Coast - School of Health and Sport Sciences
Linda Denehy (Author) - University of Melbourne
Publication details: Journal of Clinical Medicine, Vol.8(9), 1288
Publisher: MDPI AG
Date published: 2019
DOI: 10.3390/jcm8091288
ISSN: 2077-0383; 2077-0383
Copyright note: Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy; School of Health - Public Health
Language: English
Record Identifier: 99450860402621
Output Type: Journal article
Research Statement: false

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