Oral nutritional supplements for preventing surgical site infections: protocol for a systematic review and meta-analysis

Nicholas Ralph; Lindsay Brown; Kristy L. McKillop; Jed Duff; Sonya Osborne; Victoria R. Terry; Karen-Leigh Edward; Rachel King; Edward Barui

doi:10.1186/s13643-020-01293-x

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Oral nutritional supplements for preventing surgical site infections: protocol for a systematic review and meta-analysis

Journal article

Open access

Peer reviewed

Oral nutritional supplements for preventing surgical site infections: protocol for a systematic review and meta-analysis

Nicholas Ralph, Lindsay Brown, Kristy L. McKillop, Jed Duff, Sonya Osborne, Victoria R. Terry, Karen-Leigh Edward, Rachel King and Edward Barui

Systematic Reviews, Vol.9, pp.1-10

2020

DOI: https://doi.org/10.1186/s13643-020-01293-x

PMID: 32079543

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Abstract

surgical site infection

malnutrition

surgery

SSIs

Background: Surgical site infections (SSIs) are among the most common healthcare-associated infections. Under-nutrition is an important risk factor for SSIs and can lead to delayed wound healing and longer hospital stays. Oral nutritional supplements are prescribed to reduce the risk of infection and improve health status, but data from randomised controlled trials (RCTs) have shown mixed results. Thus, the objective of our planned systematic review is to evaluate oral nutritional supplements on preventing SSIs in adult surgical patients Methods: RCTs conducted in adult surgical patients who receive oral nutritional support will be included. The primary outcome will be the incidence of SSIs (within 30 days of surgery or within 90 days for joint replacement surgery). Secondary outcomes will be changes in nutritional status, mortality, health-related quality of life and costs. Literature searches will be conducted in several electronic databases (from inception onwards): MEDLINE, Embase, CINAHL and The Cochrane Central Register of Controlled Trials (CENTRAL). Grey literature will be identified through searching clinical trial registers and dissertation databases. Two reviewers will independently screen all citations, full-text articles and abstract data. The study methodological quality (or bias) will be appraised using the Cochrane risk of bias tool. If feasible, we will conduct random effects meta-analysis where appropriate. Discussion: This systematic review will evaluate the evidence for pre- and post-surgical intervention with oral nutritional supplements in adults. Findings from this planned review may inform subsequent nutritional interventions for hospitalised patients who undergo surgery.

Details

Title: Oral nutritional supplements for preventing surgical site infections: protocol for a systematic review and meta-analysis
Authors: Nicholas Ralph (Corresponding Author) - University of Southern Queensland
Lindsay Brown - University of Southern Queensland
Kristy L. McKillop - St Vincent’s Private Hospital (Australia, Toowoomba)
Jed Duff - University of Newcastle Australia
Sonya Osborne - Queensland University of Technology
Victoria R. Terry - University of Southern Queensland
Karen-Leigh Edward - Swinburne University of Technology
Rachel King - University of Southern Queensland
Edward Barui - St Vincent’s Private Hospital (Australia, Toowoomba)
Publication details: Systematic Reviews, Vol.9, pp.1-10
Publisher: BioMed Central Ltd.
Date published: 2020
DOI: 10.1186/s13643-020-01293-x
ISSN: 2046-4053
PMID: 32079543
Copyright note: © The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Data Availability: Not applicable.
Grant note: Kristy McKillop’s doctoral studies were supported by a scholarship administered through the University of Southern Queensland and funded by the Federal Government of Australia.
Organisation Unit: School of Health
Language: English
Record Identifier: 991087497702621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Nutrition & Dietetics

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