Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study)

Jeanie Cheong; Kate Lillian Iona Cameron; Deanne Thompson; Peter J Anderson; Sarath Ranganathan; Ross Clark; Benjamin Mentiplay; Alice Burnett; Katherine Lee; Lex William Doyle; Alicia J Spittle

doi:10.1136/bmjopen-2020-044491

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Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study)

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Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study)

Jeanie Cheong, Kate Lillian Iona Cameron, Deanne Thompson, Peter J Anderson, Sarath Ranganathan, Ross Clark, Benjamin Mentiplay, Alice Burnett, Katherine Lee, Lex William Doyle, …

BMJ Open, Vol.11, pp.1-9

2021

DOI: https://doi.org/10.1136/bmjopen-2020-044491

PMID: 33518527

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Abstract

Introduction: Children born moderate to late preterm (MLP, 32–36 weeks’ gestation) account for approximately 85% of all preterm births globally. Compared with children born at term, children born MLP are at increased risk of poor neurodevelopmental outcomes. Despite making up the largest group of preterm children, developmental outcomes of children born MLP are less well studied than in other preterm groups. This study aimed to (1) compare neurodevelopmental, respiratory health and brain magnetic resonance imaging (MRI) outcomes between children born MLP and term at 9 years of age; (2) examine the differences in brain growth trajectory from infancy to 9 years between children born MLP and term; and in children born MLP; (3) examine the relationship between brain development and neurodevelopment at 9 years; and (4) identify risk factors for poorer outcomes at 9 years.Methods and analysis: The ”LaPrem” (Late Preterm MRI Study) study is a longitudinal cohort study of children born MLP and term controls, born at the Royal Women’s Hospital in Melbourne, Australia, between 2010 and 2013. Participants were recruited in the neonatal period and were previously followed up at 2 and 5 years. This 9-year school-age follow-up includes neuropsychology, motor and physical activities, and lung function assessments, as well as brain MRI. Outcomes at 9 years will be compared between birth groups using linear and logistic regressions. Trajectories of brain development will be compared between birth groups using mixed effects models. The relationships between MRI and neurodevelopmental outcomes, as well as other early predictors of poor 9-year outcomes, will be explored using linear and logistic regression.Ethics and dissemination: This study was approved by the human research ethics committee at the Royal Children’s Hospital, Melbourne, Australia. Study outcomes will be disseminated through peer-reviewed publications, conference presentations and social media.

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Title: Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study)
Authors: Jeanie Cheong (Author) - The University of Melbourne
Kate Lillian Iona Cameron (Author) - The University of Melbourne
Deanne Thompson (Author) - The University of Melbourne
Peter J Anderson (Author) - Monash University
Sarath Ranganathan (Author) - The University of Melbourne
Ross Clark (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - Legacy
Benjamin Mentiplay (Author) - La Trobe University
Alice Burnett (Author) - The University of Melbourne
Katherine Lee (Author) - The University of Melbourne
Lex William Doyle (Author) - The University of Melbourne
Alicia J Spittle (Author) - The University of Melbourne
Publication details: BMJ Open, Vol.11, pp.1-9
Publisher: B M J Group
Date published: 2021
DOI: 10.1136/bmjopen-2020-044491
ISSN: 2044-6055
PMID: 33518527
Copyright note: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy; School of Health - Public Health
Language: English
Record Identifier: 99508608202621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Pediatrics

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