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Published VersionCC BY V4.0, Open Access
Journal article
Experiences of participants in a clinical trial of a novel radioactive treatment for advanced prostate cancer: A nested, qualitative longitudinal study
PLoS One, Vol.17(11), pp.1-15
2022
Abstract
Objectives
Qualitative studies nested within clinical trials can provide insight into the treatment experience, how this evolves over time and where improved supportive care is required. The purpose of this qualitative study is to describe the lived experiences of men with advanced prostate cancer participating in the TheraP trial; a randomised trial of 177Lu-PSMA-617 compared with cabazitaxel chemotherapy.
Methods
Fifteen men with advanced prostate cancer were recruited from the TheraP clinical trial with interviews conducted at three timepoints during the trial. An interpretative phenomenological approach was used, and interviews analysed using thematic analysis. This research paper reports the results from the mid-point, conclusion and follow up interviews, focusing specifically on participants’ experiences of trial participation.
Results
Three themes were identified representing the lived experiences of men with advanced prostate cancer participating in the TheraP trial: (1) facing limited options; (2) anticipating outcomes and (3) coping with health changes.
Conclusions
Men who enrol in clinical trial of anti-neoplastic treatments for prostate cancer need targeted psychological and supportive care that includes attention to unique aspects of the experience of having prostate cancer and being in a clinical trial. As part of their trial experience, men with advanced prostate cancer need to be regularly assessed for survivorship needs, fully informed, supported and referred to services for regular care and support across the trajectory of their disease.
Trial registration
NCT03392428. Registered on 8 January 2018 (ANZUP1603).
Details
- Title
- Experiences of participants in a clinical trial of a novel radioactive treatment for advanced prostate cancer: A nested, qualitative longitudinal study
- Authors
- Bianca M. Viljoen - University of Southern QueenslandMichael D. Hofman - The University of MelbourneSuzanne K Chambers - University of Southern QueenslandJeff J. Dunn - University of Southern QueenslandHaryana J. Dhillon - The University of SydneyIan Davis - Monash UniversityNicholas Ralph (Corresponding Author) - University of Southern Queensland
- Publication details
- PLoS One, Vol.17(11), pp.1-15
- Publisher
- Public Library of Science
- Date published
- 2022
- DOI
- 10.1371/journal.pone.0276063
- ISSN
- 1932-6203
- Copyright note
- © 2022 Viljoen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Data Availability
- All relevant data are within the paper and its Supporting Information files.
- Grant note
- Funding support was received from a ANZUP Below the Belt Grant (QualTheraP: a nested, multi-perspective longitudinal qualitative study of participants) (MSH, SKC, JD, HMD, IDD, NR). The National Health and Medical Research Council (NHMRC) Centre of Research Excellence provided further funding support through a PhD Scholarship (BV).
- Organisation Unit
- School of Health
- Language
- English
- Record Identifier
- 991056198902621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Oncology
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