Calf muscle density is independently associated with physical function in overweight and obese older adults

D Scott; C Shore-Lorenti; L B McMillan; J Mesinovic; Ross Clark; A Hayes; K M Sanders; G Duque; P R Ebeling

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Calf muscle density is independently associated with physical function in overweight and obese older adults

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Peer reviewed

Calf muscle density is independently associated with physical function in overweight and obese older adults

D Scott, C Shore-Lorenti, L B McMillan, J Mesinovic, Ross Clark, A Hayes, K M Sanders, G Duque and P R Ebeling

Journal of Musculoskeletal Neuronal Interactions, Vol.18(1), pp.9-17

2018

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Abstract

Neurosciences

Medical Physiology

muscle density

physical function

abdominal obesity

insulin resistance

inflammation

Objectives: To determine whether associations of calf muscle density with physical function are independent of other determinants of functional decline in overweight and obese older adults. Methods: This was a secondary analysis of a cross-sectional study of 85 community-dwelling overweight and obese adults (mean +/- SD age 62.8 +/- 7.9 years; BMI 32.3 +/- 6.1 kg/m(2); 58% women). Peripheral quantitative computed tomography assessed mid-calf muscle density (66% tibial length) and dual-energy X-ray absorptiometry determined visceral fat area. Fasting glucose, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and C-reactive protein (CRP) were analysed. Physical function assessments included hand grip and knee extension strength, balance path length (computerised posturography), stair climb test, Short Physical Performance Battery (SPPB) and self-reported falls efficacy (Modified Falls Efficacy Scale; M-FES). Results: Visceral fat area, not muscle density, was independently associated with CRP and fasting glucose (B=0.025; 95% CI 0.009-0.042 and B=0.009; 0.001-0.017, respectively). Nevertheless, higher muscle density was independently associated with lower path length and stair climb time, and higher SPPB and M-FES scores (all P<0.05). Visceral fat area, fasting glucose and CRP did not mediate these associations. Conclusions: Higher calf muscle density predicts better physical function in overweight and obese older adults independent of insulin resistance, visceral adiposity or inflammation.

Details

Title: Calf muscle density is independently associated with physical function in overweight and obese older adults
Authors: D Scott (Author) - Monash University
C Shore-Lorenti (Author) - Monash University
L B McMillan (Author) - Monash University
J Mesinovic (Author) - Monash University
Ross Clark (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
A Hayes (Author) - Australian Institute for Musculoskeletal Science (AIMSS)
K M Sanders (Author) - Australian Institute for Musculoskeletal Science (AIMSS)
G Duque (Author) - Australian Institute for Musculoskeletal Science (AIMSS)
P R Ebeling (Author) - Australian Institute for Musculoskeletal Science (AIMSS)
Publication details: Journal of Musculoskeletal Neuronal Interactions, Vol.18(1), pp.9-17
Publisher: International Society of Musculoskeletal and Neuronal Interactions
Date published: 2018
ISSN: 1108-7161
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy; School of Health - Public Health
Language: English
Record Identifier: 99450866102621
Output Type: Journal article

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