Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults

D Scott; T Trbojevic; E Skinner; Ross Clark; P Levinger; T P Haines; K M Sanders; P R Ebeling

Back

Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults

Journal article

Peer reviewed

Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults

D Scott, T Trbojevic, E Skinner, Ross Clark, P Levinger, T P Haines, K M Sanders and P R Ebeling

Journal of Musculoskeletal Neuronal Interactions, Vol.15(4), pp.350-357

2015

Files and links (1)

url

http://www.ismni.org/jmni/index.phpView

Webpage

Abstract

intermuscular adipose tissue

sarcopenia

balance

mobility

ageing

Objectives: To determine associations of inter- and intra-muscular adipose tissue (IMAT) with cardiometabolic health and physical function in older adults. Methods: 48 community-dwelling older adults aged ≥65 years (mean 71.6±4.8 years; 52% women) underwent whole-body dual-energy X-ray absorptiometry, to assess appendicular lean mass (ALM), and peripheral quantitative computed tomography (pQCT; 66% tibia), to assess calf IMAT cross-sectional area ([CSA]; cm2) and muscle density (mg/cm3; higher values indicate lower fat infiltration). Fasting glucose, lipids, triglycerides and C-reactive protein (CRP) were analysed. Physical function was assessed by postural sway (computerised posturography; N=41), and gait analysis (GAITRite Electronic Walkway; N=40). Results: Higher IMAT CSA and muscle density were associated with significantly higher (B=0.85 95%CI [0.34, 1.36]) and lower (-2.14 [-4.20, -0.08]) CRP and higher (0.93 [0.56, 1.30]) and lower postural sway (-3.12 [-4.74, -1.50]), respectively, after adjustment for age, sex and ALM/BMI. Higher IMAT CSA was associated with slower gait speed and cadence, and greater step time and step width (all P<0.03), while higher muscle density was associated with smaller step width (P<0.01) only. Conclusions: Older adults with higher calf IMAT have poorer balance, mobility and inflammatory status. Interventions aimed at improving physical function in older adults should incorporate strategies to reduce IMAT. © 2015, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.

Details

Title: Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults
Authors: D Scott (Author) - Monash University
T Trbojevic (Author) - University of Melbourne
E Skinner (Author) - Monash University
Ross Clark (Author) - Australian Catholic University
P Levinger (Author) - Victoria University
T P Haines (Author) - Monash University
K M Sanders (Author) - University of Melbourne
P R Ebeling (Author) - University of Melbourne
Publication details: Journal of Musculoskeletal Neuronal Interactions, Vol.15(4), pp.350-357
Publisher: International Society of Musculoskeletal and Neuronal Interactions
Date published: 2015
ISSN: 1108-7161
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy; School of Health - Public Health
Language: English
Record Identifier: 99451294002621
Output Type: Journal article

Metrics

759 Record Views