Abstract
Home-based rehabilitation in inoperable lung cancer: a randomised controlled trial
European Respiratory Journal, Vol.52(Supplement 62), OA5188
ERS International Congress, 2018 (Paris, France, 15-Sep-2018–19-Sep-2018)
2018
Abstract
Background: Lung cancer is associated with poor health-related quality of life (HRQoL) yet few controlled trials have assessed rehabilitation impact. Aims: Assess the efficacy of home-based rehabilitation compared with usual care (UC) at active treatment commencement for inoperable lung cancer. Methods: Multi-site, stratified, assessor-blinded RCT (concealed allocation), with intention-to-treat. Participants received UC plus 8-weeks of aerobic and resistance exercise with weekly behavior change and symptom management telephone support (intervention group [IG]) or UC. Primary outcome was between-group change in six-minute walk (6MWD) from baseline to 9-weeks. Secondary outcomes included; physical activity (PA), muscle strength, HRQoL, symptoms and exercise motivation measured at baseline, 9-weeks and 6-months (Edbrooke, L. et al. BMC Cancer 2017; 17:633). Results: 92 participants were recruited (45 IG, 47 UC): mean (SD) age 64 (12) years; male 55%; disease stage n (%) III=35 (38) and IV=48 (52); radical treatment intent n (%) 42 (46). Attrition was 15% at 9-weeks and 28% at 6-months. Median survival (days): 636 (IG), 406 (UC), p=0.15. Exercise adherence was 65% (26/40). Between-group differences in 6MWD, PA and strength were non-significant at 9-weeks or 6-months. Significant differences (mean diff (95% CI)), favouring the IG, were found at 6-months for HRQoL (FACT-L 13.0 (3.9 to 22.1), p=0.005), symptom severity (MDASI-LC -2.2 (-3.6 to -0.9, p=0.001) and exercise motivation (BREQ-2 -0.6 (-1.2 to -0.03), p=0.04). Conclusions: Home-based rehabilitation resulted in significant improvements in HRQoL, symptoms and exercise motivation at 6-month follow-up but did not change physical function outcomes.
Details
- Title
- Home-based rehabilitation in inoperable lung cancer: a randomised controlled trial
- Authors
- Lara Edbrooke (Author) - University of MelbourneSanchia Aranda (Author) - Cancer Council AustraliaCatherine Granger (Author) - University of MelbourneChristine McDonald (Author) - Austin HealthMei Krishnasamy (Author) - University of MelbourneLinda Mileshkin (Author) - Peter MacCallum Cancer CentreRoss Clark (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringIan Gordon (Author) - University of MelbourneLouis Irving (Author) - Melbourne HealthLinda Denehy (Author) - University of Melbourne
- Publication details
- European Respiratory Journal, Vol.52(Supplement 62), OA5188
- Conference details
- ERS International Congress, 2018 (Paris, France, 15-Sep-2018–19-Sep-2018)
- Publisher
- European Respiratory Society
- Date published
- 2018
- DOI
- 10.1183/13993003.congress-2018.OA5188
- ISSN
- 0903-1936
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy; School of Health - Public Health
- Language
- English
- Record Identifier
- 99450884602621
- Output Type
- Abstract
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Respiratory System