Working paper
Epigenetic and Posttranscriptional Biomarkers of PTSD: A Scoping Review Protocol
pp.1-13
University of the Sunshine Coast
2022
DOI:
https://doi.org/10.25907/00149
Abstract
Objective: The objective of this scoping review is to explore current knowledge on the genetic regulation implicated with post-traumatic stress disorder (PTSD). Thereby identifying the dysregulated expression of epigenetic and post-transcriptional biomarkers that contribute to molecular perturbations see in PTSD and their diagnostic, prognostic and therapeutic values.
Introduction: PTSD sufferers continue to re-experience symptoms long after the trauma event. Whilst, research has identified neurotransmitter systems and neurobiological mechanisms that contribute to PTSD, there is little knowledge of the genetic alterations that underpin the pathophysiology of PTSD.
Inclusion criteria: This review examines all human, animal and cell culture studies identifying epigenetic changes in participants, as a consequence of PTSD. The studies will focus on biological markers through experimental design. It will include quantitative studies, meta-analyses, genome-wide and epigenome-wide association studies.
Methods: The databases to be searched will include Web of Science, Scopus, Global Health (CABI), PubMed. The search will be supplemented by scanning reference lists of relevant reviews, and hand-searching key journals specialising in PTSD. The search will focus on English publications after 1995. The titles and abstracts and full texts will be reviewed by two independent reviewers against the inclusion criteria. Any conflicting views will be resolved by discussion or a third reviewer. The resulting data will identify validated epigenetic and post-transcriptional changes (>1.5 fold or statistical significance) and their regional location. Consequently, they will be mapped to associated neurobiological signalling
Details
- Title
- Epigenetic and Posttranscriptional Biomarkers of PTSD: A Scoping Review Protocol
- Authors
- Nathan Wellington (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteRoger Carter (Author) - University of the Sunshine Coast, Queensland, Library ServicesJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteAna Bouças (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteAnna Kuballa (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
- Publication details
- pp.1-13
- Publisher
- University of the Sunshine Coast
- Date published
- 2022
- DOI
- 10.25907/00149
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; Library Services; Thompson Institute; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99643379202621
- Output Type
- Working paper; Scoping Review Protocol
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