Preprint
The Role of Glycogenin in Normal Liver Glycogen Metabolism and Body Glucose Homeostasis
Social Science Research Network (SSRN) , Vol.17 August 2024
Elsevier
2024
Abstract
Glycogen is a glucose-storage polysaccharide molecule present in animals, fungi and bacteria. The enzyme glycogenin can self-glycosylate, forming an oligosaccharide chain that primes glycogen synthesis. This priming role of glycogenin had been believed to be essential for glycogen synthesis, but glycogenin knockout mice (Gyg KO) show glycogen in skeletal muscle, heart, liver and brain, thereby demonstrating that glycogen can be synthesized without glycogenin. Within the liver, glycogen is present in the form of individual glycogen particles, called β particles, and larger composite aggregates of linked β particles known as α particles. Previous studies suggested that liver glycogenin plays a role in linking β particles into α particles and thus participates in glucose homeostasis. Here, the function of glycogenin in the liver is explored through targeted characterization of glycogen structure and through proteomic and metabolic studies on Gyg KO mice. The results show that glycogenin is dispensable for normal liver-glycogen metabolism.
Details
- Title
- The Role of Glycogenin in Normal Liver Glycogen Metabolism and Body Glucose Homeostasis
- Authors
- Xinle Tan - The University of QueenslandGiorgia Testoni - Institute for Research in BiomedicineMitchell A Sullivan - University of the Sunshine Coast, Queensland, School of Health - BiomedicineIliana Lopez-Soldado - Institute for Research in BiomedicineFrancisco Vilaplana - The University of QueenslandRobert G Gilbert - The University of QueenslandJoan J. Guinovart - Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas AsociadasBenjamin L Schulz - The University of QueenslandJordi Duran - Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Publication details
- Social Science Research Network (SSRN) , Vol.17 August 2024
- Publisher
- Elsevier
- Date published
- 2024
- DOI
- 10.2139/ssrn.4928718
- ISSN
- 1556-5068
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991087896702621
- Output Type
- Preprint
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