Sustained activation in basal ganglia and cerebellum after repetitive movement in a non-task-specific dystonia

John K Kuster; Jacob M Levenstein; Jeff L Waugh; Trisha J Multhaupt-Buell; Myung Joo Lee; Byoung Woo Kim; Guido Pagnacco; Miriam L Makhlouf; Lewis R Sudarsky; Hans C R Breiter; Nutan Sharma; Anne J Blood

doi:10.1101/2023.03.19.533030

Preprint

Sustained activation in basal ganglia and cerebellum after repetitive movement in a non-task-specific dystonia

John K Kuster, Jacob M Levenstein, Jeff L Waugh, Trisha J Multhaupt-Buell, Myung Joo Lee, Byoung Woo Kim, Guido Pagnacco, Miriam L Makhlouf, Lewis R Sudarsky, Hans C R Breiter, …

bioRxiv, Vol.21 March 2023

Cold Spring Harbor Laboratory Press

2023

DOI: https://doi.org/10.1101/2023.03.19.533030

PMID: 36993354

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Abstract

Neurosciences

cervical dystonia

movement disorders

putamen

cerebellum

repetition

inhibition

motor control

impedance

imaging

We previously observed sustained fMRI BOLD signal in the basal ganglia in focal hand dystonia patients after a repetitive finger tapping task. Since this was observed in a task-specific dystonia, for which excessive task repetition may play a role in pathogenesis, in the current study we asked if this effect would be observed in a focal dystonia (cervical dystonia [CD]) that is not considered task-specific or thought to result from overuse. We evaluated fMRI BOLD signal time courses before, during, and after the finger tapping task in CD patients. We observed patient/control differences in post-tapping BOLD signal in left putamen and left cerebellum during the non-dominant (left) hand tapping condition, reflecting abnormally sustained BOLD signal in CD. BOLD signals in left putamen and cerebellum were also abnormally elevated in CD during tapping itself and escalated as tapping was repeated. There were no cerebellar differences in the previously studied FHD cohort, either during or after tapping. We conclude that some elements of pathogenesis and/or pathophysiology associated with motor task execution/repetition may not be limited to task-specific dystonias, but there may be regional differences in these effects across dystonias, associated with different types of motor control programs.

Details

Title: Sustained activation in basal ganglia and cerebellum after repetitive movement in a non-task-specific dystonia
Authors: John K Kuster (Author) - Massachusetts General Hospital
Jacob M Levenstein (Author) - Massachusetts General Hospital
Jeff L Waugh (Author) - Massachusetts General Hospital
Trisha J Multhaupt-Buell (Author) - Massachusetts General Hospital
Myung Joo Lee (Author) - Northwestern University
Byoung Woo Kim (Author) - University of Wyoming
Guido Pagnacco (Author) - University of Wyoming
Miriam L Makhlouf (Author) - Massachusetts General Hospital
Lewis R Sudarsky (Author) - Harvard Medical School
Hans C R Breiter (Author) - Massachusetts General Hospital
Nutan Sharma (Author) - Massachusetts General Hospital
Anne J Blood (Corresponding Author) - Massachusetts General Hospital
Publication details: bioRxiv, Vol.21 March 2023
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/2023.03.19.533030
ISSN: 2692-8205
PMID: 36993354
Organisation Unit: Thompson Institute
Language: English
Record Identifier: 99715098802621
Output Type: Preprint

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