Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization

Ruiyang Ge; Yuetong Yu; Yi Qi; Yunan Vera Fan; Shiyu Chen; Chuntong Gao; Shalaila Haas; Amirhossein Modabbernia; Faye New; Ingrid Agartz; Philip Asherson; Rosa Ayesa-Arriola; Nerisa Banaj; Tobias Banaschewski; Sarah Baumeister; Alessandro Bertolino; Dorret Boomsma; Stefan Borgwardt; Alan Breier; Josiane Bourque; Henry Brodaty; Daniel Brandeis; Rachel Brouwer; Randy Buckner; Jan Buitelaar; Dara Cannon; Xavier Caseras; Simon Cervenka; Patricia Conrod; Benedicto Crespo-Facorro; Fabrice Crivello; Eveline Crone; Liewe De Haan; Greig De Zubicaray; Annabella Di Giorgio; Susanne Erk; Simon Fisher; Barbara Franke; Thomas Frodl; David Glahn; Dominik Grotegerd; Oliver Gruber; Patricia Gruner; Raquel Gur; Ruben Gur; Ben Harrison; Sean Hatton; Ian Hickie; Fleur Howells; Hilleke E Hulshoff Pol; Chaim Huyser; Terry Jernigan; Jiyang Jiang; John Joska; Rene Kahn; Andrew Kalnin; Nicole Kochan; Sanne Koops; Jonna Kuntsi; Luisa Lazaro; Jim Lagopoulos; Irina Lebedeva; Christine Lochner; Nicholas Martin; Bernard Mazoyer; Brenna Mcdonald; Colm Mcdonald; Katie Mcmahon; Tomohiro Nakao; Lars Nyberg; Fabrizio Piras; Maria Portella; Jiang Qiu; Joshua Roffman; Perminder Sachdev; Theodore Satterthwaite; Andrew Saykin; Gunter Schumann; Carl Sellgren; Jordan Smoller; Kang Sim; Jair Soares; Iris Sommer; Gianfranco Spalletta; Dan Stein; Christian Tamnes; Sophia Thomopolous; Alexander Tomyshev; Diana Tordesillas-Gutierrez; Julian Trollor; Dennis Van 't Ent; Odile A Van Den Heuvel; Theo Gm Van Erp; Neeltje Em Van Haren; Daniela Vecchio; Dick Veltman; Henrik Walter; Yang Wang; Dongtao Wei; Wei Wen; Bernd Weber; Lars Westlye; Lara Wierenga; Steven Williams; Margaret Wright; Sarah Medland; Mon-Ju Wu; Neda Jahanshad; Paul Thompson; Sophia Frangou

doi:10.1101/2023.01.30.523509

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Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization

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Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization

Ruiyang Ge, Yuetong Yu, Yi Qi, Yunan Vera Fan, Shiyu Chen, Chuntong Gao, Shalaila Haas, Amirhossein Modabbernia, Faye New, Ingrid Agartz, …

bioRxiv, Vol.19 March 2023

Cold Spring Harbor Laboratory Press

2023

DOI: https://doi.org/10.1101/2023.01.30.523509

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Abstract

Background: Normative modeling is a statistical approach to quantify the degree to which a particular individual level measure deviates from the pattern observed in a normative reference population. When applied to human brain morphometric measures it has the potential to inform about the significance of normative deviations for health and disease. Normative models can be implemented using a variety of algorithms that have not been systematically appraised. Methods: To address this gap, eight algorithms were compared in terms of performance and computational efficiency using brain regional morphometric data from 37,407 healthy individuals (53% female; aged 3-90 years) collated from 87 international MRI datasets. Performance was assessed with the mean absolute error (MAE) and computational efficiency was inferred from central processing unit (CPU) time. The algorithms evaluated were Ordinary Least Squares Regression (OLSR), Bayesian Linear Regression (BLR), Generalized Additive Models for Location, Scale, and Shape (GAMLSS), Parametric Lambda, Mu, Sigma (LMS), Gaussian Process Regression (GPR), Warped Bayesian Linear Regression (WBLG), Hierarchical Bayesian Regression (HBR), and Multivariable Fractional Polynomial Regression (MFPR). Model optimization involved testing nine covariate combinations pertaining to acquisition features, parcellation software versions, and global neuroimaging measures (i.e., total intracranial volume, mean cortical thickness, and mean cortical surface area). Findings: Statistical comparisons across models at PFDR<0·05 indicated that the MFPR derived sex and regionspecific models with nonlinear polynomials for age and linear effects of global measures had superior predictive accuracy; the range of the MAE of the models of regional subcortical volumes was 70-520 mm3 and the corresponding ranges for regional cortical thickness and regional cortical surface area were 0·09-0·26 mm and 24-560 mm2, respectively. The MFPR derived models were also computationally more efficient with a CPU time below one second compared to a range of 2 seconds to 60 minutes for the other algorithms. The performance of all sex- and region specific MFPR models plateaued at sample sizes exceeding 3,000 and showed comparable MAEs across distinct 10 year age bins covering the human lifespan.

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Title: Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization
Authors: Ruiyang Ge (Author) - University of British Columbia
Yuetong Yu (Author) - University of British Columbia
Yi Qi (Author) - University of British Columbia
Yunan Vera Fan (Author) - University of British Columbia
Shiyu Chen (Author) - University of British Columbia
Chuntong Gao (Author) - University of British Columbia
Shalaila Haas (Author) - Icahn School of Medicine at Mount Sinai
Amirhossein Modabbernia (Author) - Icahn School of Medicine at Mount Sinai
Faye New (Author) - Icahn School of Medicine at Mount Sinai
Ingrid Agartz (Author) - University of Oslo
Philip Asherson (Author) - King's College London
Rosa Ayesa-Arriola (Author) - Marqués de Valdecilla University Hospital
Nerisa Banaj (Author)
Tobias Banaschewski (Author) - Central Institute of Mental Health
Sarah Baumeister (Author) - Central Institute of Mental Health
Alessandro Bertolino (Author) - University of Bari Aldo Moro
Dorret Boomsma (Author) - Vrije Universiteit Amsterdam
Stefan Borgwardt (Author) - University of Lübeck
Alan Breier (Author) - Indiana University
Josiane Bourque (Author) - University of Pennsylvania
Henry Brodaty (Author) - UNSW Sydney
Daniel Brandeis (Author) - Central Institute of Mental Health
Rachel Brouwer (Author) - Utrecht University
Randy Buckner (Author) - Massachusetts General Hospital
Jan Buitelaar (Author) - Radboud University Nijmegen
Dara Cannon (Author) - Ollscoil na Gaillimhe – University of Galway
Xavier Caseras (Author) - Cardiff University
Simon Cervenka (Author)
Patricia Conrod (Author) - Université de Montréal
Benedicto Crespo-Facorro (Author)
Fabrice Crivello (Author) - Institut des Maladies Neurodégénératives
Eveline Crone (Author) - Leiden University
Liewe De Haan (Author) - Amsterdam University Medical Centers
Greig De Zubicaray (Author) - Queensland University of Technology
Annabella Di Giorgio (Author) - Casa Sollievo della Sofferenza
Susanne Erk (Author) - Charité - Universitätsmedizin Berlin
Simon Fisher (Author) - Max Planck Institute for Psycholinguistics
Barbara Franke (Author) - Radboud University Nijmegen
Thomas Frodl (Author) - RWTH Aachen University
David Glahn (Author) - Boston Children's Hospital
Dominik Grotegerd (Author) - University of Münster
Oliver Gruber (Author) - Heidelberg University
Patricia Gruner (Author) - Yale University
Raquel Gur (Author) - University of Pennsylvania
Ruben Gur (Author) - University of Pennsylvania
Ben Harrison (Author) - The University of Melbourne
Sean Hatton (Author) - University of California, San Diego
Ian Hickie (Author) - The University of Sydney
Fleur Howells (Author) - University of Cape Town
Hilleke E Hulshoff Pol (Author) - University Medical Center Utrecht
Chaim Huyser (Author) - De Bascule
Terry Jernigan (Author) - University of California, San Diego
Jiyang Jiang (Author) - UNSW Sydney
John Joska (Author) - University of Cape Town
Rene Kahn (Author) - Icahn School of Medicine at Mount Sinai
Andrew Kalnin (Author) - The Ohio State University
Nicole Kochan (Author)
Sanne Koops (Author) - University Medical Center Utrecht
Jonna Kuntsi (Author) - King's College London
Luisa Lazaro (Author) - Hospital Clínic de Barcelona
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Irina Lebedeva (Author) - Mental Health Research Center of Russian Academy of Medical Sciences
Christine Lochner (Author) - Stellenbosch University
Nicholas Martin (Author) - QIMR Berghofer Medical Research Institute
Bernard Mazoyer (Author) - Université de Bordeaux
Brenna Mcdonald (Author) - Indiana University
Colm Mcdonald (Author) - Ollscoil na Gaillimhe – University of Galway
Katie Mcmahon (Author) - Queensland University of Technology
Tomohiro Nakao (Author) - Kyushu University
Lars Nyberg (Author) - Umeå University
Fabrizio Piras (Author)
Maria Portella (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Jiang Qiu (Author) - Southwest University
Joshua Roffman (Author) - Massachusetts General Hospital
Perminder Sachdev (Author) - UNSW Sydney
Theodore Satterthwaite (Author) - University of Pennsylvania
Andrew Saykin (Author) - Indiana University Health
Gunter Schumann (Author) - King's College London
Carl Sellgren (Author) - Stockholm Health Care Services
Jordan Smoller (Author) - Massachusetts General Hospital
Kang Sim (Author) - Institute of Mental Health
Jair Soares (Author) - Harris
Iris Sommer (Author) - University Medical Center Groningen
Gianfranco Spalletta (Author)
Dan Stein (Author) - University of Cape Town
Christian Tamnes (Author) - University of Oslo
Sophia Thomopolous (Author) - Stevens Institute of Technology
Alexander Tomyshev (Author) - Mental Health Research Center of Russian Academy of Medical Sciences
Diana Tordesillas-Gutierrez (Author)
Julian Trollor (Author) - UNSW Sydney
Dennis Van 't Ent (Author) - Vrije Universiteit Amsterdam
Odile A Van Den Heuvel (Author) - Amsterdam Neuroscience
Theo Gm Van Erp (Author) - University of California, Irvine
Neeltje Em Van Haren (Author) - Erasmus University Rotterdam
Daniela Vecchio (Author)
Dick Veltman (Author) - Amsterdam Neuroscience
Henrik Walter (Author) - Charité
Yang Wang (Author) - Medical College of Wisconsin
Wei Wen (Author) - UNSW Sydney
Bernd Weber (Author) - University Hospital Bonn
Dongtao Wei (Author) - Southwest University
Lars Westlye (Author) - University of Oslo
Lara Wierenga (Author) - Leiden University
Steven Williams (Author) - King's College London
Margaret Wright (Author) - The University of Queensland
Sarah Medland (Author) - The University of Queensland
Mon-Ju Wu (Author) - The University of Texas Health Science Center at Houston
Neda Jahanshad (Author) - Stevens Institute of Technology
Paul Thompson (Author) - Stevens Institute of Technology
Sophia Frangou (Corresponding Author) - University of British Columbia
Publication details: bioRxiv, Vol.19 March 2023
Publisher: Cold Spring Harbor Laboratory Press
Date published: 2023
DOI: 10.1101/2023.01.30.523509
ISSN: 2692-8205
Copyright note: The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license.
Grant note: 278948, 602450, 603016, 602805; 602450 / EU Seventh Framework Programme 667302, 643051 / EU Horizon 2020 Programme ERC‐230374 / European Research Council FKZ:01ED1615 / EU Joint ProgrammeNeurodegenerative Disease Research 496682, 1009064 / Australian National Health and Medical Research Council 01ZZ9603, 01ZZ0103, 01ZZ0403 / Federal Ministry of Education and Research 91619115, 016‐130‐669 / Vici Innovation Program 10‐000‐1001 / Dutch Health Research Council 184-033-111, 84.021.00 / Biobanking and Biomolecular Resources Research Infrastructure 223273 / Research Council of Norway 2017‐112, 2019-107, 2014‐097, 2013‐054 / South and Eastern Norway Regional Health Authority 20‐013‐00748 / Russian Foundation for Basic Research API07/011, NCT02534363, NCT0235832 / Fundación Instituto de Investigación Marqués de Valdecilla 523‐2014‐3467, 2017‐00949, 521‐2014‐3487, K2007‐62X‐15077‐04‐1, K2008‐62P‐20597‐01‐3, K2010‐62X‐15078‐07‐2, K2012‐61X‐15078‐09‐3 / Swedish Research Council Knut and Alice Wallenberg Foundation G0500092 / Medical Research Council National Institutes of Health
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99717697102621
Output Type: Preprint

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