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Increased Expression of eEF1A2 and PI3K-Akt Signaling Pathway Genes Promotes The Progression of Cervical Cancer246.02 kB
Preprint VersionCC BY V4.0, Open Access
Preprint
Increased expression of eEF1A2 and PI3K-Akt signaling pathway genes promotes the progression of cervical cancer
Research Square, Vol.4 February 2021, pp.1-20
Research Square Company
2021
Abstract
Objective: This study sought to explore the mRNA and protein expression levels of eukaryotic translation elongation factor 1 alpha 2 (eEF1A2) and members of the PI3K-Akt signaling pathway in the context of cervical cancer. We sought to clarify the expression of eEF1A2, PI3K, Akt during cervical cancer tumorigenesis and development. Methods: Samples from 72 cases of cervical cancer were collected, as well as 46 cases of cervical intraepithelial neoplasia (CIN), which reflects the continuous process of cervical cancer development, divided into CIN I, CIN II, CIN III, and 40 cases of chronic cervicitis. qRT-PCR was to detect the mRNA levels of eEF1A2, PI3K, and Akt, with β-actin used as an internal control. eEF1A2, PI3K, p-Akt protein levels in cervical cancer, CIN, and chronic cervicitis tissues were
Details
- Title
- Increased expression of eEF1A2 and PI3K-Akt signaling pathway genes promotes the progression of cervical cancer
- Authors
- Huizhen Xin (Author) - Shihezi UniversityHuan Pan (Author) - Shihezi UniversityXiangyi Zhe (Author) - Shihezi UniversityChunhe Zhang (Author) - Shihezi UniversityHongtao Li (Author) - Shihezi UniversityWeinan Zheng (Author) - Chengdu Medical CollegeRenfu Shao (Author) - University of the Sunshine Coast, Queensland, School of Science and Engineering - LegacyDongmei Li (Author) - Shihezi UniversityZemin Pan (Author) - Shihezi University
- Publication details
- Research Square, Vol.4 February 2021, pp.1-20
- Publisher
- Research Square Company
- Date published
- 2021
- DOI
- 10.21203/rs.3.rs-144942/v1
- ISSN
- 2693-5015
- Copyright note
- This work is licensed under a CC BY 4.0 License.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99508607402621
- Output Type
- Preprint
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