Global monitoring of hyperglycaemic emergencies in adults with diabetes: protocol for a systematic review of incidence and outcomes (2015–2024) [version 1; peer review: awaiting peer review]

Maisoon Mairghani; Steven James; Roopa Mehta; Dominika Bhatia; Olive James; Samira Barbara Jabakhanji; John McCaffrey; Killian Walsh; Barbara Clyne; Edward W Gregg

Global monitoring of hyperglycaemic emergencies in adults with diabetes: protocol for a systematic review of incidence and outcomes (2015–2024) [version 1; peer review: awaiting peer review]

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Global monitoring of hyperglycaemic emergencies in adults with diabetes: protocol for a systematic review of incidence and outcomes (2015–2024) [version 1; peer review: awaiting peer review]

Maisoon Mairghani, Steven James, Roopa Mehta, Dominika Bhatia, Olive James, Samira Barbara Jabakhanji, John McCaffrey, Killian Walsh, Barbara Clyne and Edward W Gregg

HRB Open Research , Vol.31 January 2025

F1000 Research Ltd

2025

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Abstract

diabetes

diabetic coma

diabetic ketoacidosis

hyperosmolar hyperglycaemic state

severe hyperglycaemia

incidence

systematic review

Background: Hyperglycaemic emergencies, such as diabetic ketoacidosis (DKA) and hyperosmolar hyperglycaemic state (HHS), are critical indicators of inadequate glucose management, and highlight issues such as lack of insulin availability, suboptimal patient education, or non-adherence to treatment. This systematic review will examine the global variation in DKA and HHS incidence, clinical outcomes and related trends, in adults with diabetes, to guide future diabetes management strategies and advocacy. Methods: The review will follow the PERSyst group guidance for conducting systematic reviews of proportions, and will be reported using Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. We will include population-based observational studies conducted in all geographic settings that report data on adult populations diagnosed with type 1 or type 2 diabetes from 2015–2024, with no language restrictions. The databases to be searched are Ovid MEDLINE, Embase, Scopus, EBSCO CINAHL, and the WHO Global Index Medicus. Using Covidence, two reviewers will independently screen titles and abstracts against eligibility criteria, review potentially relevant full-text articles, and extract data from eligible studies. A third reviewer will resolve any conflicts. Reviewers will use a standardised data extraction form to capture study population, methodological, and outcome data. The methodological quality of included studies will be assessed using the JBI Critical Appraisal tool for studies reporting prevalence data. Extracted data will be synthesised using descriptive statistics and summarised narratively. Dissemination: Findings from this systematic review will be used to inform global diabetes monitoring, prevention and treatment initiatives, and advocacy. Upon completion, the final review report will be submitted for publication to a peer-reviewed journal, and presented at scientific conferences nationally and internationally. PROSPERO registration: CRD42024588719

Details

Title: Global monitoring of hyperglycaemic emergencies in adults with diabetes: protocol for a systematic review of incidence and outcomes (2015–2024) [version 1; peer review: awaiting peer review]
Authors: Maisoon Mairghani (Author) - Royal College of Surgeons in Ireland
Steven James - University of the Sunshine Coast, Queensland, School of Health - Nursing
Roopa Mehta (Author) - Royal College of Surgeons in Ireland
Dominika Bhatia (Author) - Royal College of Surgeons in Ireland
Olive James (Author) - The University of Queensland
Samira Barbara Jabakhanji (Author) - Royal College of Surgeons in Ireland
John McCaffrey (Author) - Royal College of Surgeons in Ireland
Killian Walsh (Author) - Royal College of Surgeons in Ireland
Barbara Clyne (Author) - Royal College of Surgeons in Ireland
Edward W Gregg (Corresponding Author) - Royal College of Surgeons in Ireland
Publication details: HRB Open Research , Vol.31 January 2025
Publisher: F1000 Research Ltd
Date published: 2025
ISSN: 2515-4826
Copyright note: © 2025 Mairghani M et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Data Availability: Underlying data: No data are associated with this article. Extended data: Open Science Framework: GDC Project 2 - Global Monitoring of Hyperglycaemic Emergencies in Adults with Diabetes: A Systematic Review of Incidence and Outcomes (2015–2024), https://doi.org/10.17605/OSF.IO/6HBVQ (Mairghani et al., 2024). The following extended data are associated with this article: PRISMA-P Checklist GDC Project 2_PROSPERO_CRD42024588719 GDC Project 2_Supplementary File 1_Search Strategy.xlsx
Organisation Unit: School of Health - Nursing
Language: English
Record Identifier: 991123252202621
Output Type: Preprint

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