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Preprint VersionCC BY-NC-ND V4.0, Open Access
Preprint
GABA relates to functional connectivity changes and retention in visuomotor adaptation
bioRxiv, Vol.15 March 2021
Cold Spring Harbor Laboratory Press
2021
Abstract
Motor adaptation is fundamental to maintaining accurate movements under changing conditions, but the neurochemical basis of human motor adaptation is not well understood. Here, we used an ultra-high-field MR multimodal acquisition to address the hypothesis that M1 GABA and M1-Cerebellar functional connectivity would relate to retention of adaptation, but not acquisition of adaptation. As such, we demonstrate higher baseline M1 [GABA] relates to greater retention but does not relate to adaptation-acquisition. This relationship is mediated by change in M1-Cerebellar functional connectivity: higher M1 [GABA] relates to a decreased M1-Cerebellar connectivity, resulting in greater retention. These findings showed anatomical, neurochemical and behavioural specificity: As expected, no relationship was found between retention and a control metabolite, retention and connectivity change between control regions and between M1 [GABA] and behaviour in a control condition. The implication of a mechanistic link from neurochemistry to retention advances our understanding of population variability in retention and provides a step towards therapeutic interventions to restore motor abilities.
Details
- Title
- GABA relates to functional connectivity changes and retention in visuomotor adaptation
- Authors
- Caroline Nettekoven (Author) - University of OxfordSinead Brady (Author) - University of OxfordWilliam T Clarke (Author) - University of OxfordUzay Emir (Author) - Purdue UniversityJacob Levenstein (Author) - University of the Sunshine Coast, Queensland, Thompson InstitutePierre Petitet (Author) - University of OxfordNuriel T N Panouilleres (Author) - Université Paris-SaclayVelicia Bachtiar (Author)Jacinta O'Shea (Author) - University of OxfordHeidi Johansen-Berg (Author) - University of OxfordNed Jenkinson (Author) - University of BirminghamCharlotte Stagg (Author) - University of Oxford
- Publication details
- bioRxiv, Vol.15 March 2021
- Publisher
- Cold Spring Harbor Laboratory Press
- Date published
- 2021
- DOI
- 10.1101/2020.12.22.423981
- Copyright note
- The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99639278402621
- Output Type
- Preprint
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