Preprint
Characterising Mental Wellbeing and Associations with Subcortical Grey Matter Volume at Short Intervals in Early Adolescence
Social Science Research Network (SSRN) , Vol.7 August 2024
Elsevier
2024
Appears in Thompson Institute Research Collection
Abstract
This temporally rich, longitudinal study of early adolescents (N=88, 277 datasets, 12-13 years) investigated the relationship between bilateral subcortical grey matter volume (GMV) in the hippocampus, amygdala, accumbens-area, caudate, putamen and pallidum with self-reported mental wellbeing at four timepoints, across 12 months. Generalised Estimating Equations (GEE) revealed (1) higher ‘total wellbeing’ was associated with smaller left caudate, larger right caudate and larger left accumbens-area; (2) higher eudaimonic wellbeing was associated with smaller left caudate and larger right caudate; and (3) higher hedonic wellbeing was associated with larger left accumbens-area. Further analyses and plots highlighted different associations between GMV and wellbeing for adolescents who consistently experienced ‘moderate-to-flourishing’ wellbeing (n=63, 201 datasets) compared with those who experienced ‘languishing’ wellbeing at any timepoint (n=25, 76 datasets). These findings demonstrate several associations between subcortical GMV and measures of wellbeing, at short intervals in early adolescence. Taken together, sub-types of wellbeing appear uniquely associated with specific subcortical regions; and there may be a distinct neurobiological and wellbeing profile for adolescents who experience poorer wellbeing over the course of their first year(s) of secondary school. This study implicates the bilateral caudate and left accumbens-area as important targets for future research into the mental wellbeing of adolescents.
Details
- Title
- Characterising Mental Wellbeing and Associations with Subcortical Grey Matter Volume at Short Intervals in Early Adolescence
- Authors
- Amanda Boyes (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJacob M Levenstein - University of the Sunshine Coast, Queensland, Thompson InstituteLarisa McLoughlin - University of the Sunshine Coast, Queensland, Thompson InstituteChristina Driver - University of the Sunshine Coast, Queensland, Thompson InstituteDashiell Sacks - University of the Sunshine Coast, Queensland, Thompson InstituteKassie Bromley - University of the Sunshine Coast, Queensland, Thompson InstituteTaliah Prince - University of the Sunshine Coast, Queensland, Thompson InstituteJustine M Gatt - UNSW AustraliaJim Lagopoulos - Thompson Brain and Mind Healthcare (Australia)Daniel Hermens - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Social Science Research Network (SSRN) , Vol.7 August 2024
- Publisher
- Elsevier
- Date published
- 2024
- DOI
- 10.2139/ssrn.4903842
- ISSN
- 1556-5068
- Grant note
- LABS is supported by the Australian Commonwealth Government’s ‘Prioritizing Mental Health Initiative’ (2018-25).
- Organisation Unit
- Graduate Research School; Thompson Institute
- Language
- English
- Record Identifier
- 991087896802621
- Output Type
- Preprint
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