Patent
Method of evaluating genomic sequences
United States Patent and Trademark Office
2015
Abstract
Methods of calling genomic sequence values in complex calling regions are disclosed. Following a preliminary sequence alignment a complex calling region may be identified where no sequence values satisfy preliminary alignment criteria. Potential hypotheses may be formulated for the complex calling region and the probability of each hypothesis representing a correct alignment may be calculated by evaluating the probability of each hypothesis being correct for the reads and the probability of each hypothesis occurring. The hypothesis best satisfying hypothesis selection criteria may be selected. The method may include an evaluation of possible indels in the complex calling region.
Details
- Title
- Method of evaluating genomic sequences
- Authors
- John Gerald Cleary (Author)Mark Utting (Author) - University of the Sunshine Coast
- Contributors
- Real Time Genomics Limited (Hamilton Central, NZ) (Assignee)
- Publisher
- United States Patent and Trademark Office
- Date published
- 2015
- Patent
- US9165253B2; Family ID:49397097; Application Number: 14/015,295
- Patent agency
- United States Patent and Trademark Office (United States, Alexandria) - PTO
- Patent Coverage
- Coverage: United States
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99451496702621
- Output Type
- Patent
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