Picato® (ingenol mebutate) gel: Case Study

Jim Aylward; Peter Parsons; Andreas Suhrbier; Steven Ogbourne; Sarah-Jane Cozzi

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Picato® (ingenol mebutate) gel: Case Study

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Picato® (ingenol mebutate) gel: Case Study

Jim Aylward, Peter Parsons, Andreas Suhrbier, Steven Ogbourne and Sarah-Jane Cozzi

National Health and Medical Research Council

2018

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Abstract

Oncology and Carcinogenesis

Pharmacology and Pharmaceutical Sciences

Picato® is a prescription gel that treats skin actinic keratosis (potentially pre-cancerous sunspots). The journey to develop this product began in the 1970s when Queensland researcher, Dr Jim Aylward, became interested in a local farming story about the healing properties of the sap of the radium weed Euphorbia peplus when applied to sunspots on the skin. In the 1990s, Dr Aylward accelerated his research on the sap, and by 1997 he had teamed up with Professors Peter Parsons and Andreas Suhrbier at QIMR Berghofer, and the journey from basic science to pharmaceutical product began. NHMRC provided research fellowships and other grants to support the pre-clinical research in the Parsons and Suhrbier labs. Both credit NHMRC's support as a significant contributor, along with other public and private funding sources, to the successful commercial development of Picato® gel. In Australia, Picato® is available as a private script and is also listed on the Repatriation Pharmaceutical Benefit Scheme. Global sales in 2017 were around US$76m.

Details

Title: Picato® (ingenol mebutate) gel: Case Study
Authors: Jim Aylward (Author) - Peplin Biotech Pty Ltd
Peter Parsons (Author) - University of Queensland
Andreas Suhrbier (Author) - QIMR Berghofer
Steven Ogbourne (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Sarah-Jane Cozzi (Author) - Merck Sharp & Dohme (MSD) Australia
Publisher: National Health and Medical Research Council
Date published: 2018
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451255402621
Output Type: Other; Project Summary

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