Letter/Communication
Temporal trails of natural selection in human mitogenomes
Molecular Biology and Evolution, Vol.26(4), pp.715-717
2009
Abstract
Mildly deleterious mutations initially contribute to the diversity of a population, but later they are selected against at high frequency and are eliminated eventually. Using over 1,500 complete human mitochondrial genomes along with those of Neanderthal and Chimpanzee, I provide empirical evidence for this prediction by tracing the footprints of natural selection over time. The results show a highly significant inverse relationship between the ratio of nonsynonymous-to-synonymous divergence (dN/dS) and the age of human haplogroups. Furthermore, this study suggests that slightly deleterious mutations constitute up to 80% of the mitochondrial amino acid replacement mutations detected in human populations and that over the last 500,000 years these mutations have been gradually removed. © The Author 2009. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.
Details
- Title
- Temporal trails of natural selection in human mitogenomes
- Authors
- Sankar Subramanian (Author) - Arizona State University, United States
- Publication details
- Molecular Biology and Evolution, Vol.26(4), pp.715-717
- Publisher
- Oxford University Press
- Date published
- 2009
- DOI
- 10.1093/molbev/msp005
- ISSN
- 0737-4038
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99451292302621
- Output Type
- Letter/Communication
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