Reassessing putative antimicrobial resistance variants in Burkholderia pseudomallei: Commentary on a recent genomic analysis

Erin P Price; Derek S Sarovich

doi:10.1016/j.meegid.2025.105842

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Reassessing putative antimicrobial resistance variants in Burkholderia pseudomallei: Commentary on a recent genomic analysis

Letter/Communication

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Reassessing putative antimicrobial resistance variants in Burkholderia pseudomallei: Commentary on a recent genomic analysis

Erin P Price and Derek S Sarovich

Infection, Genetics and Evolution, Vol.135, pp.1-4

2025

DOI: https://doi.org/10.1016/j.meegid.2025.105842

PMID: 41101665

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Abstract

Melioidosis

AMR prediction

AMR

Comparative genomics

Burkholderia pseudomallei

Antimicrobial resistance

Bioinformatics

We read with great interest the recently published study by Hinwan and colleagues in Infection, Genetics and Evolution (Hinwan et al., 2025). Their study reports valuable data for 16 Thai Burkholderia pseudomallei genomes – 13 of which are publicly available – that exhibit antimicrobial resistance (AMR) towards at least one clinically relevant antibiotic: amoxicillin/clavulanate (AMC), ceftazidime (CAZ), meropenem (MEM), or co-trimoxazole (SXT). Their study also examined 22 previously published AMR strains from Australia (n = 21) and Thailand (n = 1). The genomes of these 38 AMR strains were compared with 300 antimicrobial-susceptible strains to help elucidate known and putative novel AMR genetic variants. Although we appreciate their study design, we believe that certain results merit further consideration and analysis.

Details

Title: Reassessing putative antimicrobial resistance variants in Burkholderia pseudomallei: Commentary on a recent genomic analysis
Authors: Erin P Price (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Derek S Sarovich - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Publication details: Infection, Genetics and Evolution, Vol.135, pp.1-4
Publisher: Elsevier BV
Date published: 2025
DOI: 10.1016/j.meegid.2025.105842
ISSN: 1567-7257
PMID: 41101665
Data Availability: Our latest ARDaP-compatible B. pseudomallei AMR variant database is available at: https://github.com/dsarov/ARDaP/tree/master/Databases/Burkholderia_pseudomallei_k96243
Grants: Using metagenomics to improve antimicrobial resistance detection and treatment in chronic obstructive pulmonary disease (COPD), 2039264, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Grant note: Wishlist Foundation (CRG-2023-09)
Organisation Unit: School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 991173177102621
Output Type: Letter/Communication

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