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Published VersionCC BY-NC V4.0, Open Access
Published VersionCC BY-NC V4.0, Open
Letter/Communication
Reassessing putative antimicrobial resistance variants in Burkholderia pseudomallei: Commentary on a recent genomic analysis
Infection, Genetics and Evolution, Vol.135, pp.1-4
2025
PMID: 41101665
Abstract
We read with great interest the recently published study by Hinwan and colleagues in Infection, Genetics and Evolution (Hinwan et al., 2025). Their study reports valuable data for 16 Thai Burkholderia pseudomallei genomes – 13 of which are publicly available – that exhibit antimicrobial resistance (AMR) towards at least one clinically relevant antibiotic: amoxicillin/clavulanate (AMC), ceftazidime (CAZ), meropenem (MEM), or co-trimoxazole (SXT). Their study also examined 22 previously published AMR strains from Australia (n = 21) and Thailand (n = 1). The genomes of these 38 AMR strains were compared with 300 antimicrobial-susceptible strains to help elucidate known and putative novel AMR genetic variants. Although we appreciate their study design, we believe that certain results merit further consideration and analysis.
Details
- Title
- Reassessing putative antimicrobial resistance variants in Burkholderia pseudomallei: Commentary on a recent genomic analysis
- Authors
- Erin P Price (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for BioinnovationDerek S Sarovich - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
- Publication details
- Infection, Genetics and Evolution, Vol.135, pp.1-4
- Publisher
- Elsevier BV
- Date published
- 2025
- DOI
- 10.1016/j.meegid.2025.105842
- ISSN
- 1567-7257; 1567-1348
- PMID
- 41101665
- Copyright note
- © 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/bync/4.0/).
- Data Availability
- Our latest ARDaP-compatible B. pseudomallei AMR variant database is available at: https://github.com/dsarov/ARDaP/tree/master/Databases/Burkholderia_pseudomallei_k96243
- Grant note
- Wishlist Foundation (CRG-2023-09)
- Organisation Unit
- School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991173177102621
- Output Type
- Letter/Communication
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