Files and links (2)
n-3 PUFAs improve erythrocyte fatty acid profile in patients with small abdominal aortic aneurysms - a randomised controlled trial658.29 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
n-3 PUFAs improve erythrocyte fatty acid profile in patients with small abdominal aortic aneurysms: a randomised controlled trial
Journal of Lipid Research, Vol.60(6), pp.1154-1163
2019
Abstract
Abdominal aortic aneurysm (AAA) is an important cause of death in older adults which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyte fatty acid content in 43 AAA patients (diameter 3.0-4.5 cm) and 52 healthy controls. In addition, the effect of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation on erythrocyte fatty acid content was examined in a cohort of 30 AAA patients as part of a 12-week randomised placebo-controlled clinical trial. Blood analyses identified associations between AAA and decreased linoleic acid, and AAA and increased Δ6-desaturase activity and biosynthesis of arachidonic acid from linoleic acid. n-3 PUFA supplementation (1.5g DHA+0.3g EPA/day) decreased red blood cell distribution width (RDW, 14.8±0.4% to 13.8±0.2%, p=0.003) and levels of pro-inflammatory n-6 PUFAs (arachidonic acid, 12.46±0.23% to 10.14±0.3%, P<0.001; adrenic acid 2.12±0.13% to 1.23±0.09%, p<0.001). In addition, Δ4-desaturase activity increased (docosahexaenoic/docosapentaenoic acid ratio, 1.85±0.14 to 3.93±0.17, P<0.001) and elongase 2/5 activity decreased (adrenic acid/arachidonic acid ratio, 0.17±0.01 to 0.12±0.01, P<0.01) following supplementation. The findings suggest n-3 PUFAs improve fatty acid profiles and ameliorate factors associated with inflammation in AAA patients.
Details
- Title
- n-3 PUFAs improve erythrocyte fatty acid profile in patients with small abdominal aortic aneurysms: a randomised controlled trial
- Authors
- Lara T Meital (Author) - University of the Sunshine Coast - School of Health & Sport SciencesMark Windsor (Author) - University of the Sunshine Coast - School of Health & Sport SciencesRebecca M L Ramirez Jewell (Author) - University of the Sunshine Coast - School of Health & Sport SciencesPeter Young (Author) - University of the Sunshine CoastKarl Schulze (Author) - Sunshine VascularRebecca Magee (Author) - Sunshine Coast University HospitalJill O'Donnell (Author) - Sunshine Coast University HospitalPankaj Jha (Author) - Sunshine Coast University HospitalMaria-Christina Perissiou (Author) - University of the Sunshine Coast - School of Health & Sport SciencesJonathan Golledge (Author) - James Cook UniversityTom G Bailey (Author) - University of the Sunshine Coast - School of Health & Sport SciencesPeter R Brooks (Author) - University of the Sunshine Coast - School of Health & Sport SciencesChristopher D Askew (Author) - University of the Sunshine Coast - School of Health & Sport SciencesFraser D Russell (Author) - University of the Sunshine Coast - School of Health & Sport Sciences
- Publication details
- Journal of Lipid Research, Vol.60(6), pp.1154-1163
- Publisher
- American Society for Biochemistry and Molecular Biology, Inc.
- Date published
- 2019
- DOI
- 10.1194/jlr.P093013
- ISSN
- 0022-2275
- Copyright note
- Copyright © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- Organisation Unit
- School of Health - Biomedicine; School of Science and Engineering - Legacy; UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; Academic Support Unit; School of Science, Technology and Engineering; School of Health - Sports & Exercise Science; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99451429702621
- Output Type
- Journal article
Metrics
13 File views/ downloads
833 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Biochemistry & Molecular Biology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites