dbEMT: an epithelial-mesenchymal transition associated gene resource

Min Zhao; Lei Kong; Yining Liu; Hong Qu

doi:10.1038/srep11459

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dbEMT: an epithelial-mesenchymal transition associated gene resource

Journal article

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dbEMT: an epithelial-mesenchymal transition associated gene resource

Min Zhao, Lei Kong, Yining Liu and Hong Qu

Scientific Reports, Vol.5(11459), pp.1-14

2015

DOI: https://doi.org/10.1038/srep11459

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Abstract

epithelial-mesenchymal transition (EMT)

As a cellular process that changes epithelial cells to mesenchymal cells, Epithelial-mesenchymal transition (EMT) plays important roles in development and cancer metastasis. Recent studies on cancer metastasis have identified many new susceptibility genes that control this transition. However, there is no comprehensive resource for EMT by integrating various genetic studies and the relationship between EMT and the risk of complex diseases such as cancer are still unclear. To investigate the cellular complexity of EMT, we have constructed dbEMT (http://dbemt.bioinfominzhao. org/), the first literature-based gene resource for exploring EMT-related human genes. We manually curated 377 experimentally verified genes from literature. Functional analyses highlighted the prominent role of proteoglycans in tumor metastatic cascades. In addition, the disease enrichment analysis provides a clue for the potential transformation in affected tissues or cells in Alzheimer's disease and Type 2 Diabetes. Moreover, the global mutation pattern of EMT-related genes across multiple cancers may reveal common cancer metastasis mechanisms. Our further reconstruction of the EMT-related protein-protein interaction network uncovered a highly modular structure. These results illustrate the importance of dbEMT to our understanding of cell development and cancer metastasis, and also highlight the utility of dbEMT for elucidating the functions of EMTrelated genes.

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Title: dbEMT: an epithelial-mesenchymal transition associated gene resource
Authors: Min Zhao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Lei Kong (Author) - Peking University, China
Yining Liu (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Hong Qu (Author) - Peking University, China
Publication details: Scientific Reports, Vol.5(11459), pp.1-14
Publisher: Nature Publishing Group
Date published: 2015
DOI: 10.1038/srep11459
ISSN: 2045-2322
Copyright note: Copyright © 2015 The Author. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99449192302621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology

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