dbCPG: A web resource for cancer predisposition genes

Ran Wei; Yao Yao; Wu Yang; Chun-Hou Zheng; Min Zhao; Junfeng Xia

doi:10.18632/oncotarget.9334

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dbCPG: A web resource for cancer predisposition genes

Journal article

Open access

Peer reviewed

dbCPG: A web resource for cancer predisposition genes

Ran Wei, Yao Yao, Wu Yang, Chun-Hou Zheng, Min Zhao and Junfeng Xia

Oncotarget, Vol.7(25), pp.37803-37811

2016

DOI: https://doi.org/10.18632/oncotarget.9334

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Abstract

cancer predisposition gene

database

functional annotation

gene prioritization

network module

Cancer predisposition genes (CPGs) are genes in which inherited mutations confer highly or moderately increased risks of developing cancer. Identification of these genes and understanding the biological mechanisms that underlie them is crucial for the prevention, early diagnosis, and optimized management of cancer. Over the past decades, great efforts have been made to identify CPGs through multiple strategies. However, information on these CPGs and their molecular functions is scattered. To address this issue and provide a comprehensive resource for researchers, we developed the Cancer Predisposition Gene Database (dbCPG, Database URL: http://bioinfo.ahu.edu. cn:8080/dbCPG/index.jsp), the first literature-based gene resource for exploring human CPGs. It contains 827 human (724 protein-coding, 23 non-coding, and 80 unknown type genes), 637 rats, and 658 mouse CPGs. Furthermore, data mining was performed to gain insights into the understanding of the CPGs data, including functional annotation, gene prioritization, network analysis of prioritized genes and overlap analysis across multiple cancer types. A user-friendly web interface with multiple browse, search, and upload functions was also developed to facilitate access to the latest information on CPGs. Taken together, the dbCPG database provides a comprehensive data resource for further studies of cancer predisposition genes.

Details

Title: dbCPG: A web resource for cancer predisposition genes
Authors: Ran Wei (Author) - Anhui University, China
Yao Yao (Author) - Anhui University, China
Wu Yang (Author) - Anhui University, China
Chun-Hou Zheng (Author) - Anhui University, China
Min Zhao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Junfeng Xia (Author) - Anhui University, China
Publication details: Oncotarget, Vol.7(25), pp.37803-37811
Publisher: Impact Journals LLC
Date published: 2016
DOI: 10.18632/oncotarget.9334
ISSN: 1949-2553
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450695802621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Cell Biology; Oncology

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