World human neutrophil antigens investigation survey

Behnaz  Bayat; Jonas  Lowack; Marie  Audrain; Laure  Croisille; Brian  Curtis; Rebecca  Dangerfield; Behnaz  Esmaeili; Claudia  Grabowski; Margaret  Keller; Hyungsuk  Kim; Hartmut  Kroll; Marjeta Macek  Kvanka; Janette Kwok; Elyse  Moritz; Oytip  Nathalang; Derrick  Nelson; Kaspar René  Nielsen; Gail  Pahn; Anthony  Poles; Leendert  Porcelijn; Ulrich J.  Sachs; Marlies  Schönbacher; Günther F. Körmöczi; Pawinee Kupatawintu; Daisuke Takahashi; Malgorzata Uhrynowska; Brigitte Katharina Flesch; Lin Fung

doi:10.1111/vox.13500

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World human neutrophil antigens investigation survey

Journal article

Open access

Peer reviewed

World human neutrophil antigens investigation survey

Behnaz Bayat, Jonas Lowack, Marie Audrain, Laure Croisille, Brian Curtis, Rebecca Dangerfield, Behnaz Esmaeili, Claudia Grabowski, Margaret Keller, Hyungsuk Kim, …

Vox Sanguinis, Vol.118(9), pp.763-774

2023

DOI: https://doi.org/10.1111/vox.13500

PMID: 37608544

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Abstract

HNA

TRALI

alloantibody

autoantibody

autoimmune

neutropenia

neutrophil

Background and objectives: Human neutrophil antigens (HNAs) are categorized into five systems: HNA-1 to HNA-5. Given the importance of neutrophils in immunity, we sought to create awareness of the role of HNA diagnostic services in managing immune neutropenia and transfusion-related acute lung injury. To provide health communities all around the world with access to these services, we conducted a survey to create a directory of these HNA diagnostic services. Materials and methods: An Excel table-based survey was created to capture information on the laboratory's location and was emailed to 55 individuals with known or possible HNA investigation activity. The collected data were then summarized and analysed. Results: Of contacted laboratories, the surveys were returned from 23 (38.2%) laboratories; 17 have already established HNA diagnostic (of them 12 were regular participants of the International Granulocyte Immunobiology Workshop [ISBT-IGIW]), 4 laboratories were in the process of establishing their HNA investigation and the remaining 2 responder laboratories, did not conduct HNA investigations. In established laboratories, investigation for autoimmune neutropenia (infancies and adults) was the most frequently requested, and antibodies against HNA-1a and HNA-1b were the most commonly detected. Conclusion: The directory of survey respondents provides a resource for health professionals wanting to access HNA diagnostic services. The present study offers a comprehensive picture of HNA diagnostics (typing and serology), identifying weak points and areas for improvement for the first time. Identifying more laboratories involved in HNA diagnostics with limited access to international societies in the field will globally improve HNA diagnostics.

Details

Title: World human neutrophil antigens investigation survey
Authors: Behnaz Bayat (Corresponding Author) - Justus-Liebig-Universität Gießen
Jonas Lowack (Author) - Justus-Liebig-Universität Gießen
Marie Audrain (Author) - Laboratoire de Biologie du Développement
Laure Croisille (Author)
Brian Curtis (Author)
Rebecca Dangerfield (Author) - American Red Cross
Behnaz Esmaeili (Author) - Aja University of Medical Sciences
Claudia Grabowski (Author) - DRK-Blutspendedienst Baden-Württemberg - Hessen
Margaret Keller (Author) - American Red Cross
Hyungsuk Kim (Author) - Seoul National University Hospital
Hartmut Kroll (Author) - DRK-Blutspendedienst Baden-Württemberg - Hessen
Marjeta Macek Kvanka (Author) - Blood Transfusion Centre of Slovenia
Janette Kwok (Author) - Queen Mary Hospital
Elyse Moritz (Author) - Federal University of Sao Paulo
Oytip Nathalang (Author) - Thammasat University
Derrick Nelson (Author) - South African National Blood Service
Kaspar René Nielsen (Author) - Aalborg University Hospital
Gail Pahn (Author) - Australian Red Cross Lifeblood
Anthony Poles (Author) - NHS Blood and Transplant
Leendert Porcelijn (Author) - Sanquin
Ulrich J. Sachs (Author) - Justus-Liebig-Universität Gießen
Marlies Schönbacher (Author) - Medical University of Vienna
Günther F. Körmöczi (Author) - Medical University of Vienna
Pawinee Kupatawintu (Author) - Thai Red Cross Society
Daisuke Takahashi (Author) - Japanese Red Cross Society, Japan
Malgorzata Uhrynowska (Author)
Brigitte Katharina Flesch (Author)
Lin Fung (Author) - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
Publication details: Vox Sanguinis, Vol.118(9), pp.763-774
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2023
DOI: 10.1111/vox.13500
ISSN: 1423-0410
PMID: 37608544
Copyright note: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivsLicense, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99746795402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Hematology

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