Journal article
Will urbanisation affect the expression level of genes related to cancer of wild great tits?
Science of the Total Environment, Vol.714, pp.1-6
2020
PMID: 32018940
Abstract
Recent studies suggest that oncogenic processes (from precancerous lesions to metastatic cancers) are widespread in wild animal species, but their importance for ecosystem functioning is still underestimated by evolutionary biologists and animal ecologists. Similar to what has been observed in humans, environmental modifications that often place wild organisms into an evolutionary trap and/or exposes them to a cocktail of mutagenic and carcinogenic pollutants might favor cancer emergence and progression, if animals do not up-regulate their defenses against these pathologies. Here, we compared, for the first time, the expression of 59 tumor-suppressor genes in blood and liver tissues of urban and rural great tits (Parus major); urban conditions being known to favor cancer progression due to, among other things, exposure to chemical or light pollution. Contrary to earlier indications, once we aligned the transcriptome to the great tit genome, we found negligible differences in the expression of anti-cancer defenses between urban and rural birds in blood and liver. Our results indicate the higher expression of a single caretaker gene (i.e. BRCA1) in livers of rural compared to urban birds. We conclude that, while urban birds might be exposed to an environment favoring the development of oncogenic processes, they seem to not upregulate their cancer defenses accordingly and future studies should confirm this result by assessing more markers of cancer defenses. This may result in a mismatch that might predispose urban birds to higher cancer risk and future studies in urban ecology should take into account this, so far completely ignored, hazard.
Details
- Title
- Will urbanisation affect the expression level of genes related to cancer of wild great tits?
- Authors
- Mathieu Giraudeau (Corresponding Author) - Centre de Recherche en Écologie et Évolution de la SantéHannah Watson (Author) - Lund UniversityDaniel Powell (Author) - Lund UniversityOrsolya Vincze (Author) - Babeș-Bolyai UniversityFrederic Thomas (Author) - Centre de Recherche en Écologie et Évolution de la SantéTuul Sepp (Author) - University of TartuBeata Ujvari (Author) - Deakin UniversityGuillaume Le Loc'h (Author) - École Nationale Vétérinaire de ToulouseCaroline Isaksson (Author) - Lund University
- Publication details
- Science of the Total Environment, Vol.714, pp.1-6
- Publisher
- Elsevier BV
- DOI
- 10.1016/j.scitotenv.2019.135793
- ISSN
- 1879-1026
- PMID
- 32018940
- Organisation Unit
- School of Science and Engineering - Legacy; School of Science, Technology and Engineering; University of the Sunshine Coast, Queensland; Centre for Bioinnovation; Office of Research
- Language
- English
- Record Identifier
- 99494308702621
- Output Type
- Journal article
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