Wide-field choroidal thickness and vascularity index in myopes and emmetropes

Negareh Yazdani; Asieh Ehsaei; Hosein Hoseini-Yazdi; Nasser Shoeibi; David Alonso-Caneiro; Michael J Collins

doi:10.1111/opo.12875

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Wide-field choroidal thickness and vascularity index in myopes and emmetropes

Journal article

Peer reviewed

Wide-field choroidal thickness and vascularity index in myopes and emmetropes

Negareh Yazdani, Asieh Ehsaei, Hosein Hoseini-Yazdi, Nasser Shoeibi, David Alonso-Caneiro and Michael J Collins

Ophthalmic & Physiological Optics, Vol.41(6), pp.1308-1319

2021

DOI: https://doi.org/10.1111/opo.12875

PMID: 34487376

Abstract

choroidal thickness

choroidal vascularity index

emmetropia

luminal

myopia

stromal

Purpose: To study regional variations in choroidal thickness (CT), luminal thickness and stromal thickness of the choroid, and choroidal vascularity index (CVI) in low myopic and emmetropic eyes using wide-field optical coherence tomography (OCT). Methods: Sixty-nine healthy young adults between 20 and 38 years of age participated in this study, including 40 low myopes (mean ± SD spherical equivalent (MSE) refractive error: −3.00 ± 1.39 D, range: −6.00 to −0.62 D) and 29 emmetropes (MSE: −0.05 ± 0.09 D, range: −0.25 to +0.12 D). Wide-field CT, luminal thickness, stromal thickness and CVI were measured across five eccentricities (fovea, parafovea, perifovea; near-periphery and periphery) and four quadrants (nasal, temporal, inferior and superior), in vertical and horizontal meridians, while controlling for a range of extraneous factors potentially influencing the CT. Custom-written software was used to segment and binarize the OCT images. Results: Wide-field CT, luminal thickness and stromal thickness, averaged across all participants, exhibited significant topographical variation, with the foveal (379 ± 8 µm, 200 ± 4 µm, 179 ± 4 µm, respectively) and peripheral (275 ± 8 µm, 161 ± 4 µm, 114 ± 4 µm, respectively) regions presenting the thickest and thinnest regions (all p < 0.001). Wide-field CVI showed a progressively higher percentage (greater vascularity) with increasing eccentricity from the fovea towards the periphery (p < 0.001). Macular CT and stromal choroidal thickness were significantly thinner in myopes compared to emmetropes (p < 0.05). Myopes (55.7 ± 0.3%) showed a slightly higher CVI compared with emmetropes (54.4 ± 0.4%) (p < 0.05). Conclusions: Low myopia in young adults was associated with significant choroidal thinning across the macular, but not extramacular regions, with this decrease in choroidal thickness mostly attributed to thinning in the stromal component of the choroid, rather than the luminal (vascular) component.

Details

Title: Wide-field choroidal thickness and vascularity index in myopes and emmetropes
Authors: Negareh Yazdani (Author) - Mashhad University of Medical Sciences
Asieh Ehsaei (Author) - Mashhad University of Medical Sciences
Hosein Hoseini-Yazdi (Corresponding Author) - Queensland University of Technology
Nasser Shoeibi (Author) - Mashhad University of Medical Sciences
David Alonso-Caneiro (Author) - Queensland University of Technology
Michael J Collins (Author) - Queensland University of Technology
Publication details: Ophthalmic & Physiological Optics, Vol.41(6), pp.1308-1319
Publisher: Wiley-Blackwell Publishing Ltd.
DOI: 10.1111/opo.12875
ISSN: 1475-1313
PMID: 34487376
Grant note: This work was supported by the Refractive Errors Research Centre at the Mashhad University of Medical Sciences and the Deputy of Research at the Mashhad University of Medical Sciences, Iran (Grant number: 990637).
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 99973596902621
Output Type: Journal article