White matter tractography in early psychosis: Clinical and neurocognitive associations

S N Hatton; Jim Lagopoulos; Daniel F Hermens; I B Hickie; E Scott; Maxwell Bennett

doi:10.1503/jpn.130280

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White matter tractography in early psychosis: Clinical and neurocognitive associations

Journal article

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White matter tractography in early psychosis: Clinical and neurocognitive associations

S N Hatton, Jim Lagopoulos, Daniel F Hermens, I B Hickie, E Scott and Maxwell Bennett

Journal of Psychiatry and Neuroscience, Vol.39(6), pp.417-427

2014

DOI: https://doi.org/10.1503/jpn.130280

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Abstract

Background: While many diffusion tensor imaging (DTI) investigations have noted disruptions to white matter integrity in individuals with chronic psychotic disorders, fewer studies have been conducted in young people at the early stages of disease onset. Using whole tract reconstruction techniques, the aim of this study was to identify the white matter pathology associated with the common clinical symptoms and executive function impairments observed in young people with psychosis. Methods: We obtained MRI scans from young people with psychosis and healthy controls. Eighteen major white matter tracts were reconstructed to determine group differences in fractional anisotropy (FA), axial diffusivity (AD) and radial diffusivity (RD) and then were subsequently correlated with symptomatology and neurocognitive performance. Results: Our study included 42 young people with psychosis (mean age 23 yr) and 45 healthy controls (mean age 25 yr). Compared with the control group, the psychosis group had reduced FA and AD in the left inferior longitudinal fasciculus (ILF) and forceps major indicative of axonal disorganization, reduction and/or loss. These changes were associated with worse overall psychiatric symptom severity, increases in positive and negative symptoms, and worse current levels of depression. The psychosis group also showed FA reductions in the left superior longitudinal fasciculus that were associated with impaired neurocognitive performance in attention and semantic fluency. Limitations: Our analysis grouped 4 subcategories of psychosis together, and a larger follow-up study comparing affective and nonaffective psychoses is warranted. Conclusion: Our findings suggest that impaired axonal coherence in the left ILF and forceps major underpin psychiatric symptoms in young people in the early stages of psychosis. © 2014 Canadian Medical Association.

Details

Title: White matter tractography in early psychosis: Clinical and neurocognitive associations
Authors: S N Hatton (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
E Scott (Author) - University of Sydney
Maxwell Bennett (Author) - University of Sydney
Publication details: Journal of Psychiatry and Neuroscience, Vol.39(6), pp.417-427
Publisher: Canadian Medical Association
Date published: 2014
DOI: 10.1503/jpn.130280
ISSN: 1180-4882
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449375302621
Output Type: Journal article

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