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White matter disturbances in major depressive disorder - a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group2.01 MB
Published VersionCC BY V4.0, Open Access
Journal article
White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
Molecular Psychiatry, Vol.25(7), pp.1511-1525
2020
PMID: 31471575
Appears in Thompson Institute Research Collection
Abstract
Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12–88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and effects were meta-analyzed across studies. We observed subtle, but widespread, lower fractional anisotropy (FA) in adult MDD patients compared with controls in 16 out of 25 WM tracts of interest (Cohen’s d between 0.12 and 0.26). The largest differences were observed in the corpus callosum and corona radiata. Widespread higher radial diffusivity (RD) was also observed (all Cohen’s d between 0.12 and 0.18). Findings appeared to be driven by patients with recurrent MDD and an adult age of onset of depression. White matter microstructural differences in a smaller sample of adolescent MDD patients and controls did not survive correction for multiple testing. In this coordinated and harmonized multisite DTI study, we showed subtle, but widespread differences in WM microstructure in adult MDD, which may suggest structural disconnectivity in MDD.
Details
- Title
- White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
- Authors
- Laura S van Velzen (Corresponding Author) - The University of MelbourneSinead Kelly (Author) - Harvard Medical SchoolDmitry Isaev (Author) - University of Southern CaliforniaAndre Aleman (Author) - University of GroningenLyubomir I Aftanas (Author) - Novosibirsk State UniversityJochen Bauer (Author) - University of MünsterBernhard T Baune (Author) - University of MünsterIvan V Brak (Author) - Novosibirsk State UniversityAngela Carballedo (Author) - Trinity College DublinColm G Connolly (Author) - University of California, San FranciscoBaptiste Couvy-Duchesne (Author) - The University of QueenslandKathryn R Cullen (Author) - University of MinnesotaKonstantin V Danilenko (Author) - Institute of Physiology and Basic MedicineUdo Dannlowski (Author) - University of MünsterVerena Enneking (Author) - University of MünsterElena Filimonova (Author) - Institute of Physiology and Basic MedicineKatharina Förster (Author) - University of MünsterThomas Frodl (Author) - Trinity College DublinIan H Gotlib (Author) - Stanford UniversityNynke A Groenewold (Author) - University of Cape TownDominik Grotegerd (Author) - University of MünsterMathew A Harris (Author) - University of EdinburghSean N Hatton (Author) - The University of SydneyEmma L Hawkins (Author) - University of EdinburghIan B Hickie (Author) - The University of SydneyTiffany C Ho (Author) - University of California, San FranciscoAndreas Jansen (Author) - Philipps University of MarburgTilo Kircher (Author) - Philipps University of MarburgBonnie Klimes-Dougan (Author) - University of MinnesotaPeter Kochunov (Author) - University of Maryland, Baltimore CountyAxel Krug (Author) - Philipps University of MarburgJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteRenick Lee (Author) - Institute of Mental HealthTristram A Lett (Author) - Berlin Institute of Health at Charité - Universitätsmedizin BerlinMeng Li (Author) - Universitätsaugenklinik MagdeburgFrank P MacMaster (Author) - University of CalgaryNicholas G Martin (Author) - QIMR Berghofer Medical Research InstituteAndrew M McIntosh (Author) - University of EdinburghQuinn McLellan (Author) - University of CalgarySusanne Meinert (Author) - University of MünsterIgor Nenadić (Author) - Philipps University of MarburgEvgeny Osipov (Author) - Novosibirsk State UniversityBrenda W. J. H Penninx (Author) - Amsterdam UMC - Vrije Universiteit AmsterdamMaria J Portella (Author) - Centro de Investigación Biomédica en Red de Salud MentalJonathan Repple (Author) - University of MünsterAnnerine Roos (Author) - Stellenbosch UniversityMatthew D Sacchet (Author) - Harvard Medical SchoolPhilipp G Sämann (Author) - Max Planck Institute of PsychiatryKnut Schnell (Author) - Heidelberg, GermanyXueyi Shen (Author) - University of EdinburghKang Sim (Author) - Institute of Mental HealthDan J Stein (Author) - University of Cape TownMarie-Jose van Tol (Author) - University of GroningenAlexander S Tomyshev (Author) - Mental Health Research Center of Russian Academy of Medical SciencesLeonardo Tozzi (Author) - Stanford UniversityIlya M Veer (Author) - Berlin Institute of Health at Charité - Universitätsmedizin BerlinRobert Vermeiren (Author) - Leiden UniversityYolanda Vives-Gilabert (Author) - Universitat Politècnica de ValènciaHenrik Walter (Author) - Humboldt-Universität zu BerlinMartin Walter (Author) - University of TübingenNic J. A van der Wee (Author) - Leiden University Medical CenterSteven J. A van der Werff (Author) - Leiden University Medical CenterMelinda Westlund Schreiner (Author) - University of MinnesotaHeather C Whalley (Author) - University of EdinburghMargaret J Wright (Author) - The University of QueenslandTony T Yang (Author) - University of California, San FranciscoAlyssa Zhu (Author) - University of Southern CaliforniaDick J Veltman (Author) - Amsterdam UMC Location Vrije Universiteit AmsterdamPaul M Thompson (Author) - University of Southern CaliforniaNeda Jahanshad (Author) - University of Southern CaliforniaLianne Schmaal (Author) - The University of Melbourne
- Publication details
- Molecular Psychiatry, Vol.25(7), pp.1511-1525
- Publisher
- Nature Publishing Group
- Date published
- 2020
- DOI
- 10.1038/s41380-019-0477-2
- ISSN
- 1476-5578; 1359-4184
- PMID
- 31471575
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99498808802621
- Output Type
- Journal article
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- Web Of Science research areas
- Biochemistry & Molecular Biology
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- Psychiatry
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