White Matter Integrity According to the Stage of Mental Disorder in Youth

Dashiell Sacks; Jim Lagopoulos; Sean N Hatton; Frank Iorfino; Joanne S Carpenter; Jacob J Crouse; Sharon L Naismith; Elizabeth M Scott; Ian B Hickie; Daniel Hermens

doi:10.1016/j.pscychresns.2020.111218

Back

White Matter Integrity According to the Stage of Mental Disorder in Youth

Journal article

Peer reviewed

White Matter Integrity According to the Stage of Mental Disorder in Youth

Dashiell Sacks, Jim Lagopoulos, Sean N Hatton, Frank Iorfino, Joanne S Carpenter, Jacob J Crouse, Sharon L Naismith, Elizabeth M Scott, Ian B Hickie and Daniel Hermens

Psychiatry Research: Neuroimaging, Vol.307, 111218

2021

DOI: https://doi.org/10.1016/j.pscychresns.2020.111218

Appears in Thompson Institute Research Collection

Files and links (1)

url

https://doi.org/10.1016/j.pscychresns.2020.111218View

Published Version

Abstract

white matter

diffusion tensor imaging

clinical staging

psychiatric disorder

youth

cognition

neuroimaging

Youth mental health

Thompson Institute Special Collection

UniSC Diversity Area - Disability and Inclusion

UniSC Diversity Area - Life Stages

The present study investigated differences in white matter (WM) integrity between 96 young people with affective and/or psychotic symptoms classified at an early stage of mental disorder (i.e. ‘attenuated syndrome’; stage 1b), 85 young people classified at a more advanced stage of mental disorder (i.e. ‘discrete disorder’; stage 2), and 81 demographically matched healthy controls using diffusion tensor imaging. The relationship between WM integrity (indexed by fractional anisotropy; FA) across the tracts and neuropsychological functioning was also investigated. A significant reduction in FA was identified in those with more advanced disorder in the body of the corpus callosum. Clinical stage groups were associated with significant neuropsychological impairment, which was significantly greater in those with discrete disorders. Compared to those in the earlier stage of disorder, participants at the later clinical stage showed decreased FA in the body of the corpus callosum that was associated with worse performance in attentional set formation maintenance, shifting and flexibility. These results provide further support for clinical staging of mental disorder and highlight the potential for utilising neuroanatomical biomarkers to support the classification of stages of mental disorder in the future.

Details

Title: White Matter Integrity According to the Stage of Mental Disorder in Youth
Authors: Dashiell Sacks (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Sean N Hatton (Author) - University of California San Diego
Frank Iorfino (Author) - The University of Sydney
Joanne S Carpenter (Author)
Jacob J Crouse (Author) - The University of Sydney
Sharon L Naismith (Author) - The University of Sydney
Elizabeth M Scott (Author) - The University of Sydney
Ian B Hickie (Author) - The University of Sydney
Daniel Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Publication details: Psychiatry Research: Neuroimaging, Vol.307, 111218
Publisher: Elsevier Ireland Ltd.
Date published: 2021
DOI: 10.1016/j.pscychresns.2020.111218
ISSN: 1872-7506
Grants: Optimising early interventions for young people with emerging mood disorder, 1061043, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Australian Government Research Training Program (RTP) Scholarship, RTP, Department of Education (Australia, Canberra)
An evaluation of the efficacy of cognitive remediation in depression, 402864, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Grant note: National Health & Medical Research Council (NHMRC) Australia Fellowship (No. 511921* awarded to IBH)
Organisation Unit: Thompson Institute
Language: English
Record Identifier: 99487108102621
Output Type: Journal article

Metrics

61 Record Views

5 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neuroimaging; Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites