When euthymia is just not good enough: The neuropsychology of bipolar disorder

A Olley; G S Malhi; P B Mitchell; J Batchelor; Jim Lagopoulos; M P V Austin

doi:10.1097/01.nmd.0000161684.35904.f4

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When euthymia is just not good enough: The neuropsychology of bipolar disorder

Journal article

Peer reviewed

When euthymia is just not good enough: The neuropsychology of bipolar disorder

A Olley, G S Malhi, P B Mitchell, J Batchelor, Jim Lagopoulos and M P V Austin

Journal of Nervous and Mental Disease, Vol.193(5), pp.323-330

2005

DOI: https://doi.org/10.1097/01.nmd.0000161684.35904.f4

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Abstract

bipolar disorder

neuropsychology

theory of mind

euthymia

mania

depression

Bipolar disorder (BD) is a debilitating psychiatric illness that is uniquely characterized by switching between psychopathologically contrasting phases of mania and depression, often with intervening periods of euthymia. However, these periods of apparent clinical recovery (euthymia) are marked by subtle social, occupational, and cognitive impairments, profiled by recent neuropsychological investigations. Determining the cognitive changes across these three phases may help differentiate the disruptions that are mood state-dependent from those associated with underlying pathology. This article therefore critically reviews the reported neuropsychological impairments in BD and the methodological limitations facing such research. Integration of the available evidence, principally from the field of neuropsychology, when synthesized, implicates the prefrontal cortex in the etiopathogenesis of BD and posits cortical-subcortical-limbic disruption in recovered euthymic patients that manifests as cognitive dysfunction. Copyright © 2005 by Lippincott Williams & Wilkins.

Details

Title: When euthymia is just not good enough: The neuropsychology of bipolar disorder
Authors: A Olley (Author) - University of New South Wales
G S Malhi (Author) - University of New South Wales
P B Mitchell (Author) - University of New South Wales
J Batchelor (Author) - University of New South Wales
Jim Lagopoulos (Author) - University of New South Wales
M P V Austin (Author) - University of New South Wales
Publication details: Journal of Nervous and Mental Disease, Vol.193(5), pp.323-330
Publisher: Lippincott Williams & Wilkins
Date published: 2005
DOI: 10.1097/01.nmd.0000161684.35904.f4
ISSN: 0022-3018
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449239402621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Clinical Neurology; Psychiatry

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