Journal article
What is the prevalence, and what are the clinical correlates, of insulin resistance in young people presenting for mental health care? A cross-sectional study
BMJ Open, Vol.9(5), e025674
2019
Appears in Thompson Institute Research Collection
Abstract
Objectives To report the distribution and predictors of insulin resistance (IR) in young people presenting to primary care-based mental health services. Design Cross-sectional. Setting Headspace-linked clinics operated by the Brain and Mind Centre of the University of Sydney. Participants 768 young people (66% female, mean age 19.7±3.5, range 12-30 years). Main outcome measures IR was estimated using the updated homeostatic model assessment (HOMA2-IR). Height and weight were collected from direct measurement or self-report for body mass index (BMI). Results For BMI, 20.6% of the cohort were overweight and 10.2% were obese. However, <1% had an abnormally high fasting blood glucose (>6.9 mmol/L). By contrast, 9.9% had a HOMA2-IR score >2.0 (suggesting development of IR) and 11.7% (n=90) had a score between 1.5 and 2. Further, there was a positive correlation between BMI and HOMA2-IR (r=0.44, p<0.001). Participants in the upper third of HOMA2-IR scores are characterised by younger age, higher BMIs and depression as a primary diagnosis. HOMA2-IR was predicted by younger age (β=0.19, p<0.001) and higher BMI (β=0.49, p<0.001), together explaining 22% of the variance (F(2,361)=52.1, p<0.001). Conclusions Emerging IR is evident in a significant subgroup of young people presenting to primary care-based mental health services. While the major modifiable risk factor is BMI, a large proportion of the variance is not accounted for by other demographic, clinical or treatment factors. Given the early emergence of IR, secondary prevention interventions may need to commence prior to the development of full-threshold or major mood or psychotic disorders.
Details
- Title
- What is the prevalence, and what are the clinical correlates, of insulin resistance in young people presenting for mental health care? A cross-sectional study
- Authors
- E M Scott (Author) - University of SydneyJ S Carpenter (Author) - University of SydneyF Iorfino (Author) - University of SydneyS P Cross (Author) - University of SydneyDaniel F Hermens (Author) - University of SydneyJ Gehue (Author) - University of SydneyC Wilson (Author) - University of SydneyD White (Author) - University of SydneyS L Naismith (Author) - University of SydneyA J Guastella (Author) - University of SydneyI B Hickie (Author) - University of Sydney
- Publication details
- BMJ Open, Vol.9(5), e025674
- Publisher
- B M J Group
- Date published
- 2019
- DOI
- 10.1136/bmjopen-2018-025674
- ISSN
- 2044-6055
- Copyright note
- Copyright © 2019 The Authors. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99450727802621
- Output Type
- Journal article
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- Psychiatry
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