Vitamin D Status and Skin Cancer Risk Independent of Time Outdoors: 11-Year Prospective Study in an Australian Community

Jolieke C van der Pols; Anne Russell; Ulrike Bauer; Rachel E Neale; Michael G Kimlin; Adele C Green

doi:10.1038/jid.2012.346

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Vitamin D Status and Skin Cancer Risk Independent of Time Outdoors: 11-Year Prospective Study in an Australian Community

Journal article

Peer reviewed

Vitamin D Status and Skin Cancer Risk Independent of Time Outdoors: 11-Year Prospective Study in an Australian Community

Jolieke C van der Pols, Anne Russell, Ulrike Bauer, Rachel E Neale, Michael G Kimlin and Adele C Green

Journal of Investigative Dermatology, Vol.133(3), pp.637-641

2013

DOI: https://doi.org/10.1038/jid.2012.346

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Abstract

Clinical Sciences

Oncology and Carcinogenesis

Vitamin D may have anti-skin cancer effects, but population-based evidence is lacking. We therefore assessed associations between vitamin D status and skin cancer risk in an Australian subtropical community. We analyzed prospective skin cancer incidence for 11 years following baseline assessment of serum 25(OH)-vitamin D in 1,191 adults (average age 54 years) and used multivariable logistic regression analysis to adjust risk estimates for age, sex, detailed assessments of usual time spent outdoors, phenotypic characteristics, and other possible confounders. Participants with serum 25(OH)-vitamin D concentrations above 75 nmol l-1 versus those below 75 nmol l-1 more often developed basal cell carcinoma (odds ratio (OR)=1.51 (95% confidence interval (CI): 1.10-2.07, P=0.01) and melanoma (OR=2.71 (95% CI: 0.98-7.48, P=0.05)). Squamous cell carcinoma incidence tended to be lower in persons with serum 25(OH)-vitamin D concentrations above 75 nmol l-1 compared with those below 75 nmol l-1 (OR=0.67 (95% CI: 0.44-1.03, P=0.07)). Vitamin D status was not associated with skin cancer incidence when participants were classified as above or below 50 nmol l-1 25(OH)-vitamin D. Our findings do not indicate that the carcinogenicity of high sun exposure can be counteracted by high vitamin D status. High sun exposure is to be avoided as a means to achieve high vitamin D status.

Details

Title: Vitamin D Status and Skin Cancer Risk Independent of Time Outdoors: 11-Year Prospective Study in an Australian Community
Authors: Jolieke C van der Pols (Author) - Queensland Institute of Medical Research
Anne Russell (Author) - Queensland Institute of Medical Research
Ulrike Bauer (Author) - Queensland University of Technology
Rachel E Neale (Author) - Queensland Institute of Medical Research
Michael G Kimlin (Author) - Queensland University of Technology
Adele C Green (Author) - Queensland Institute of Medical Research
Publication details: Journal of Investigative Dermatology, Vol.133(3), pp.637-641
Publisher: Nature Publishing Group
Date published: 2013
DOI: 10.1038/jid.2012.346
ISSN: 0022-202X
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99450934102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Dermatology

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