Visual Displays that Directly Interface and Provide Read-Outs of Molecular States via Molecular Graphics Processing Units

Julia E Poje; Tamara Kastratovic; Andrew R Macdonald; Ana C Guillermo; Steven E Troetti; Omar J Jabado; Leigh Fanning; Darko Stefanovic; Joanne Macdonald

doi:10.1002/anie.201402698

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Visual Displays that Directly Interface and Provide Read-Outs of Molecular States via Molecular Graphics Processing Units

Journal article

Peer reviewed

Visual Displays that Directly Interface and Provide Read-Outs of Molecular States via Molecular Graphics Processing Units

Julia E Poje, Tamara Kastratovic, Andrew R Macdonald, Ana C Guillermo, Steven E Troetti, Omar J Jabado, Leigh Fanning, Darko Stefanovic and Joanne Macdonald

Angewandte Chemie, Vol.126(35), pp.9376-9379

2014

DOI: https://doi.org/10.1002/anie.201402698

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Abstract

biosensoren

DNA-Computer

molekulare automaten

molekulare funktionseinheiten

nanotechnologie

The monitoring of molecular systems usually requires sophisticated technologies to interpret nanoscale events into electronic-decipherable signals. We demonstrate a new method for obtaining read-outs of molecular states that uses graphics processing units made from molecular circuits. Because they are made from molecules, the units are able to directly interact with molecular systems. We developed deoxyribozyme-based graphics processing units able to monitor nucleic acids and output alphanumerical read-outs via a fluorescent display. Using this design we created a molecular 7-segment display, a molecular calculator able to add and multiply small numbers, and a molecular automaton able to diagnose Ebola and Marburg virus sequences. These molecular graphics processing units provide insight for the construction of autonomous biosensing devices, and are essential components for the development of molecular computing platforms devoid of electronics.

Details

Title: Visual Displays that Directly Interface and Provide Read-Outs of Molecular States via Molecular Graphics Processing Units
Authors: Julia E Poje (Author) - Columbia University, United States
Tamara Kastratovic (Author) - Columbia University, United States
Andrew R Macdonald (Author) - Interfathom, United States
Ana C Guillermo (Author) - Columbia University, United States
Steven E Troetti (Author) - Columbia University, United States
Omar J Jabado (Author) - Mount Sinai School of Medicine, United States
Leigh Fanning (Author) - University of New Mexico, United States
Darko Stefanovic (Author) - University of New Mexico, United States
Joanne Macdonald (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Angewandte Chemie, Vol.126(35), pp.9376-9379
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
Date published: 2014
DOI: 10.1002/anie.201402698
ISSN: 0044-8249
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99448634602621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Chemistry, Multidisciplinary

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