Virulence characteristics of Escherichia coli strains causing acute cystitis in young adults in Iran

Mohammad Katouli; A Brauner; L K Haghigbi; B Kaijser; V Muratov; R Mollby

doi:10.1016/j.jinf.2004.05.021

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Virulence characteristics of Escherichia coli strains causing acute cystitis in young adults in Iran

Journal article

Peer reviewed

Virulence characteristics of Escherichia coli strains causing acute cystitis in young adults in Iran

Mohammad Katouli, A Brauner, L K Haghigbi, B Kaijser, V Muratov and R Mollby

The Journal of infection, Vol.50(4), pp.312-321

2005

DOI: https://doi.org/10.1016/j.jinf.2004.05.021

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Abstract

Escherichia coli

cystitis

virulence properties

antibiotic resistance

Escherichia coli strains that cause cystitis posses virulence properties that facilitate their colonisation and persistence in the bladder. In Iran, despite the high number of the urinary tract infections, very few studies has been done to determine the role of these virulence properties in the pathogenesis of E. coli cyctitis. Eighty-seven strains of E. coli, isolated from young adults with cystitis in Shiraz, Iran, were examined for the expression of type 1 and P-fimbriae, mannose resistant haemagglutination, haemolysin production, aerobactin-mediated iron uptake, O:K serotypes, biochemical phenotypes (BPTs) and their antibiotic susceptibility patterns. Seventy-six percent of the strains expressed multiple virulence properties. There was a significant correlation between the presence of aerobactin and the expression of type 1 fimbriae. All P-fimbriated strains produced aerobactin with 50% of them also coexpressing haemolysin. Of the 29 different O:K serotypes identified, 42% belonged to serotypes not commonly found among European serotypes associated with UTI. Strains of O groups 4 and 6 expressed more virulence factors than the others. A high resistance against ampicillin, trimethoprim and cotrimoxasol was observed among the isolates with 53% of the isolates showing multiresistance to these three antibiotics. We conclude that certain colonal groups of E. coli are commonly associated with cystitis in young adults in Iran with strains possessing a combination of aerobactin and type 1 fimbriae being the dominant ones and belonging to serotypes not commonly found in Europe.

Details

Title: Virulence characteristics of Escherichia coli strains causing acute cystitis in young adults in Iran
Authors: Mohammad Katouli (Author) - University of the Sunshine Coast - Faculty of Science, Health and Education
A Brauner (Author) - Karolinska Hospital, Sweden
L K Haghigbi (Author) - University of Shiraz, Iran
B Kaijser (Author) - Gothenburg University, Sweden
V Muratov (Author) - Karolinska Institute, Sweden
R Mollby (Author) - Karolinska Institute, Sweden
Publication details: The Journal of infection, Vol.50(4), pp.312-321
Publisher: W.B. Saunders Co. Ltd
Date published: 2005
DOI: 10.1016/j.jinf.2004.05.021
ISSN: 0163-4453
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99448837102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Infectious Diseases

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