Journal article
Versatile spider venom peptides and their medical and agricultural applications
Toxicon, Vol.158, pp.109-126
2019
Abstract
Spiders have been evolving complex and diverse repertoires of peptides in their venoms with vast pharmacological activities for more than 300 million years. Spiders use their venoms for prey capture and defense, hence they contain peptides that target both prey (mainly arthropods) and predators (other arthropods or vertebrates). This includes peptides that potently and selectively modulate a range of targets such as ion channels, receptors and signaling pathways involved in physiological processes. The contribution of these targets in particular disease pathophysiologies makes spider venoms a valuable source of peptides with potential therapeutic use. In addition, peptides with insecticidal activities, used for prey capture, can be exploited for the development of novel bioinsecticides for agricultural use. Although we have already reviewed potential applications of spider venom peptides as therapeutics (in 2010) and as bioinsecticides (in 2012), a considerable number of research articles on both topics have been published since, warranting an updated review. Here we explore the most recent research on the use of spider venom peptides for both medical and agricultural applications.
Details
- Title
- Versatile spider venom peptides and their medical and agricultural applications
- Authors
- N J Saez (Author) - University of QueenslandVolker Herzig (Author) - University of Queensland
- Publication details
- Toxicon, Vol.158, pp.109-126
- Publisher
- Elsevier Ltd.
- Date published
- 2019
- DOI
- 10.1016/j.toxicon.2018.11.298
- ISSN
- 0041-0101; 0041-0101
- Copyright note
- Copyright © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99451417202621
- Output Type
- Journal article
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- Toxicology
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