Ventilatory and hyperkalemic responses to incremental exercise after propranolol treatment

D A Schneider; M T McEniery; Colin Solomon; J Jurimae; M S Wehr

doi:10.1152/jappl.1994.77.4.1907

Back

Ventilatory and hyperkalemic responses to incremental exercise after propranolol treatment

Journal article

Peer reviewed

Ventilatory and hyperkalemic responses to incremental exercise after propranolol treatment

D A Schneider, M T McEniery, Colin Solomon, J Jurimae and M S Wehr

Journal of Applied Physiology, Vol.77(4), pp.1907-1912

1994

DOI: https://doi.org/10.1152/jappl.1994.77.4.1907

Files and links (1)

url

https://doi.org/10.1152/jappl.1994.77.4.1907View

Published Version

Abstract

Biological Sciences

Medical and Health Sciences

exercise ventilation

The purpose of the present study was to examine the relationship of plasma potassium (K+) and minute ventilation (VE) during incremental cycling (20 W/2 min) under conditions of beta-adrenergic blockade (80 mg of propranolol) and placebo in six untrained male subjects. No significant differences existed between treatments in O2 uptake, CO2 production, blood lactate, pH, or VE during the submaximal work stages of incremental exercise common to both treatments (20-220 W). During exercise with beta-blockade, plasma K+ concentrations were found to be significantly elevated compared with control levels at every work stage except 20 W. Significant positive correlations between VE and plasma K+ were found during both beta-blockade (r = 0.99) and control conditions (r = 1.00). Although the high correlation between VE and K+ was not altered with beta-blockade, propranolol treatment resulted in a significant reduction in the slope of this relationship during incremental exercise (P < 0.01). These findings suggest that 1) beta-blockade decreases the VE-K+ relationship observed during exercise and 2) K+ stimulation of muscle afferents is not an important signal in the control of exercise ventilation.

Details

Title: Ventilatory and hyperkalemic responses to incremental exercise after propranolol treatment
Authors: D A Schneider (Author) - Northeastern University, United States
M T McEniery (Author) - Northeastern University, United States
Colin Solomon (Author) - Northeastern University, United States
J Jurimae (Author) - Northeastern University, United States
M S Wehr (Author) - Northeastern University, United States
Publication details: Journal of Applied Physiology, Vol.77(4), pp.1907-1912
Publisher: American Physiological Society
Date published: 1994
DOI: 10.1152/jappl.1994.77.4.1907
ISSN: 8750-7587
Organisation Unit: Centre for Human Factors and Systems Science; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99448750202621
Output Type: Journal article

Metrics

831 Record Views

10 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Physiology; Sport Sciences