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Published VersionCC BY V4.0, Open Access
Journal article
Venom biotechnology: casting light on nature's deadliest weapons using synthetic biology
Frontiers in Bioengineering and Biotechnology, Vol.11, pp.1-17
2023
PMID: 37207126
Abstract
Venoms are complex chemical arsenals that have evolved independently many times in the animal kingdom. Venoms have attracted the interest of researchers because they are an important innovation that has contributed greatly to the evolutionary success of many animals, and their medical relevance offers significant potential for drug discovery. During the last decade, venom research has been revolutionized by the application of systems biology, giving rise to a novel field known as venomics. More recently, biotechnology has also made an increasing impact in this field. Its methods provide the means to disentangle and study venom systems across all levels of biological organization and, given their tremendous impact on the life sciences, these pivotal tools greatly facilitate the coherent understanding of venom system organization, development, biochemistry, and therapeutic activity. Even so, we lack a comprehensive overview of major advances achieved by applying biotechnology to venom systems. This review therefore considers the methods, insights, and potential future developments of biotechnological applications in the field of venom research. We follow the levels of biological organization and structure, starting with the methods used to study the genomic blueprint and genetic machinery of venoms, followed gene products and their functional phenotypes. We argue that biotechnology can answer some of the most urgent questions in venom research, particularly when multiple approaches are combined together, and with other venomics technologies.
Details
- Title
- Venom biotechnology: casting light on nature's deadliest weapons using synthetic biology
- Authors
- Tim Luddecke (Corresponding Author) - Fraunhofer Institute for Molecular Biology and Applied EcologyAnne Paas (Author) - Fraunhofer Institute for Molecular Biology and Applied EcologyRichard Harris - The University of QueenslandLea Talmann (Author) - SyngentaKim N Kirchhoff (Author) - Fraunhofer Institute for Molecular Biology and Applied EcologyAndre Billion (Author) - Fraunhofer Institute for Molecular Biology and Applied EcologyKornelia Hardes (Author) - Fraunhofer Institute for Molecular Biology and Applied EcologyAntje Steinbrink (Author) - LOEWE Centre for Translational Biodiversity GenomicsDoreen Gerlach (Author) - Fraunhofer Institute for Molecular Biology and Applied EcologyBryan G Fry (Author) - The University of QueenslandAndreas Vilcinskas (Author) - Fraunhofer Institute for Molecular Biology and Applied Ecology
- Publication details
- Frontiers in Bioengineering and Biotechnology, Vol.11, pp.1-17
- Publisher
- Frontiers Research Foundation
- Date published
- 2023
- DOI
- 10.3389/fbioe.2023.1166601
- ISSN
- 2296-4185
- PMID
- 37207126
- Copyright note
- ©2023 Lüddecke, Paas, Harris, Talmann, Kirchhoff, Billion, Hardes, Steinbrink, Gerlach, Fry and Vilcinskas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not complywith these terms.
- Grant note
- We are grateful for the generous funding provided by the Hessian Ministry of Higher Education, Research and the Arts (HMWK) via the LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG) for the project “Animal Venomics”. Funding was acquired by AV.
- Organisation Unit
- Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991177843802621
- Output Type
- Journal article
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