Vascular endothelial growth factor gene polymorphisms and ovarian cancer survival

Felicity Lose; C M Nagle; T O'Mara; J Batra; K L Bolton; H Song; S J Ramus; A Gentry-Maharaj; U Menon; S A Gayther; P D P Pharoah; M A Kedda; A B Spurdle

doi:10.1016/j.ygyno.2010.08.014

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Vascular endothelial growth factor gene polymorphisms and ovarian cancer survival

Journal article

Peer reviewed

Vascular endothelial growth factor gene polymorphisms and ovarian cancer survival

Felicity Lose, C M Nagle, T O'Mara, J Batra, K L Bolton, H Song, S J Ramus, A Gentry-Maharaj, U Menon, S A Gayther, …

Gynecologic Oncology, Vol.119(3), pp.479-483

2010

DOI: https://doi.org/10.1016/j.ygyno.2010.08.014

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Abstract

vascular endothelial growth factor

ovarian cancer

survival

polymorphisms

Objectives: We sought to evaluate the effect of polymorphisms in the VEGF (Vascular Endothelial Growth Factor) gene on overall survival in ovarian cancer patients. Methods: A sample of 319 women diagnosed with primary invasive epithelial ovarian cancer in Australia between 1985 and 1997, recruited as incident cases, were genotyped for four VEGF single nucleotide polymorphisms (three tagSNPs and one functional SNP) using the Sequenom MassARRAY platform. A SNP found to be associated with ovarian cancer survival in this sample set was then evaluated in two independent datasets in an attempt to replicate the association. Results: VEGF tagSNPs rs3025033 and rs2146323 were not associated with ovarian cancer survival in the Australian sample. Ovarian cancer patients homozygous for tagSNP rs833068 or the functional SNP rs2010963 displayed significantly shortened overall survival in the Australian sample (HR 2.09, 95% CI 1.16-3.78), an effect most apparent in the first 5 years after diagnosis. This association was not replicated in two independent datasets. Conclusions: Findings from this study provide no evidence that rs3025033 and rs2146323 VEGF polymorphisms are associated with ovarian cancer survival. Although homozygous carriers of the tagSNP rs833068 experienced significantly worse survival in our Australian dataset, we were unable to replicate this in two independent datasets. © 2010 Elsevier Inc. All rights reserved.

Details

Title: Vascular endothelial growth factor gene polymorphisms and ovarian cancer survival
Authors: Felicity Lose (Author) - Queensland Institute of Medical Research
C M Nagle (Author) - Queensland Institute of Medical Research
T O'Mara (Author) - Queensland Institute of Medical Research
J Batra (Author) - Queensland University of Technology
K L Bolton (Author) - University of Cambridge, United Kingdom
H Song (Author) - University of Cambridge, United Kingdom
S J Ramus (Author) - University College London, United Kingdom
A Gentry-Maharaj (Author) - University College London, United Kingdom
U Menon (Author) - University College London, United Kingdom
S A Gayther (Author) - University College London, United Kingdom
P D P Pharoah (Author) - University of Cambridge, United Kingdom
M A Kedda (Author) - Queensland University of Technology
A B Spurdle (Author) - Queensland Institute of Medical Research
Publication details: Gynecologic Oncology, Vol.119(3), pp.479-483
Publisher: Academic Press
Date published: 2010
DOI: 10.1016/j.ygyno.2010.08.014
ISSN: 0090-8258
Organisation Unit: University of the Sunshine Coast, Queensland; Office of Research
Language: English
Record Identifier: 99450516602621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Obstetrics & Gynecology; Oncology

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