Variations in the APOE allele or BDNF Val66Met polymorphism are not associated with changes in cognitive function following a tertiary education intervention in older adults: The Tasmanian Healthy Brain Project

Megan E Thow; Mathew J Summers; Jeffery J Summers; Nichole L Saunders; James C Vickers

doi:10.1016/j.neurobiolaging.2017.03.028

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Variations in the APOE allele or BDNF Val66Met polymorphism are not associated with changes in cognitive function following a tertiary education intervention in older adults: The Tasmanian Healthy Brain Project

Journal article

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Peer reviewed

Variations in the APOE allele or BDNF Val66Met polymorphism are not associated with changes in cognitive function following a tertiary education intervention in older adults: The Tasmanian Healthy Brain Project

Megan E Thow, Mathew J Summers, Jeffery J Summers, Nichole L Saunders and James C Vickers

Neurobiology of Aging, Vol.55, pp.175-176

2017

DOI: https://doi.org/10.1016/j.neurobiolaging.2017.03.028

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Abstract

apolipoprotein

APOE

BDNF

cognition

education

episodic memory

executive function

language

older adults

working memory

The APOE É›4 allele and the Met variant of the BDNF Val66Met polymorphism are associated with reduced cognitive function in older adults. The aim of this study was to examine the independent and interactional effect of the APOE É›4 allele and BDNF Val66Met polymorphism on cognitive function in a cohort of healthy older adults who had undertaken further university level education. Multiple group Latent Growth Curve Modelling revealed no change in cognitive function over time in APOE É›4-carriers or in BDNF Met-carriers, nor in carriers of both APOE-É›4 and BDNF-Met alleles. Further, the results indicate that allelic variation in either APOE or BDNF does not modify the beneficial effects of a university based education intervention on cognitive function over a four-year period following the intervention.

Details

Title: Variations in the APOE allele or BDNF Val66Met polymorphism are not associated with changes in cognitive function following a tertiary education intervention in older adults: The Tasmanian Healthy Brain Project
Authors: Megan E Thow (Author) - University of Tasmania
Mathew J Summers (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Jeffery J Summers (Author) - University of Tasmania
Nichole L Saunders (Author) - University of Tasmania
James C Vickers (Author) - University of Tasmania
Publication details: Neurobiology of Aging, Vol.55, pp.175-176
Publisher: Elsevier Inc.
Date published: 2017
DOI: 10.1016/j.neurobiolaging.2017.03.028
ISSN: 0197-4580
Organisation Unit: School of Health; School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450919602621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Geriatrics & Gerontology; Neurosciences

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