Journal article
Variants of human papillomaviruses 16 (HPV16) in Uigur women in Xinjiang, China
Infectious Agents and Cancer, Vol.11, 44
2016
Abstract
Background: Persistent infection of high-risk human papillomaviruses 16 (HPV16) has been considered as the leading cause of cervical cancer. In this study we assessed HPV16 sequence variation and genetic diversity of HPV16 variants in cervical cancer in Uigur women in Xinjiang, China. We analyzed the nucleotide sequences of the open reading frames of E6 and E7, and part of the open reading frames of L1 of HPV16 in Uigur women. Methods: Biopsies of histologically confirmed HPV16 infections with cervical cancer were obtained from 43 Uigur women in Xinjiang, China. E6, E7 and L1 genes of HPV16 of all samples were amplified and sequenced; the sequences were used in phylogenetic analysis of HPV16 variants. Results: Our analysis revealed nine nucleotide changes in E6 (five changes), E7 (one change) and L1 (three changes) gene. The most frequently observed variations were T350G (79.1 %). One variation T295G (D64E) at E6 were detected in 6 cases (KT959536, KT959542, KT959546, KT959550, KT959553, KT959558). Deletion (464Asp) along with insertion (448Ser) were observed in L1 (100 %). Most variants were European lineage (97.7 %); only one belongs to Asia variants with common T178G (D25E) in E6 and A647G (N29S) in E7. Conclusion: The most prevalent HPV16 variants in the Uigur women we studied were of the European lineage. Our results indicate that HPV16 European lineage may serve as a harmful factor associated with the development and progression of cervical cancer.
Details
- Title
- Variants of human papillomaviruses 16 (HPV16) in Uigur women in Xinjiang, China
- Authors
- Hongchang He (Author) - Shihezi University, ChinaHongtao Li (Author) - Shihezi University, ChinaPeiwen Fan (Author) - Shihezi University, ChinaJunling Zhu (Author) - First People Hospital of Kashga, ChinaZhenzhen Pan (Author) - Shihezi University, ChinaHuan Pan (Author) - Shihezi University, ChinaDan Wu (Author) - Shihezi University, ChinaXianxian Ren (Author) - Shihezi University, ChinaXiaoqing Guo (Author) - Shihezi University, ChinaDongmei Li (Author) - Shihezi University, ChinaZemin Pan (Author) - Shihezi University, ChinaRenfu Shao (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- Infectious Agents and Cancer, Vol.11, 44; 8
- Publisher
- BioMed Central Ltd.
- Date published
- 2016
- DOI
- 10.1186/s13027-016-0089-2
- ISSN
- 1750-9378
- Copyright note
- Copyright © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450800902621
- Output Type
- Journal article
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