Variable virulence factors in Burkholderia pseudomallei (Melioidosis) associated with human disease

Derek S Sarovich; Erin P Price; J R Webb; L M Ward; M Y Voutsinos; A Tuanyok; M Mayo; M Kaestli; B J Currie

doi:10.1371/journal.pone.0091682

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Variable virulence factors in Burkholderia pseudomallei (Melioidosis) associated with human disease

Journal article

Open access

Peer reviewed

Variable virulence factors in Burkholderia pseudomallei (Melioidosis) associated with human disease

Derek S Sarovich, Erin P Price, J R Webb, L M Ward, M Y Voutsinos, A Tuanyok, M Mayo, M Kaestli and B J Currie

PLoS One, Vol.9(3), e91682

2014

DOI: https://doi.org/10.1371/journal.pone.0091682

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Abstract

Burkholderia pseudomallei is a Gram-negative environmental bacterium that causes melioidosis, a potentially life-threatening infectious disease affecting mammals, including humans. Melioidosis symptoms are both protean and diverse, ranging from mild, localized skin infections to more severe and often fatal presentations including pneumonia, septic shock with multiple internal abscesses and occasionally neurological involvement. Several ubiquitous virulence determinants in B. pseudomallei have already been discovered. However, the molecular basis for differential pathogenesis has, until now, remained elusive. Using clinical data from 556 Australian melioidosis cases spanning more than 20 years, we identified a Burkholderia mallei-like actin polymerization bimABm gene that is strongly associated with neurological disease. We also report that a filamentous hemagglutinin gene, fhaB3, is associated with positive blood cultures but is negatively correlated with localized skin lesions without sepsis. We show, for the first time, that variably present virulence factors play an important role in the pathogenesis of melioidosis. Collectively, our study provides a framework for assessing other non-ubiquitous bacterial virulence factors and their association with disease, such as candidate loci identified from large-scale microbial genome-wide association studies. © 2014 Sarovich et al.

Details

Title: Variable virulence factors in Burkholderia pseudomallei (Melioidosis) associated with human disease
Authors: Derek S Sarovich (Author) - Menzies School of Health Research
Erin P Price (Author) - Menzies School of Health Research
J R Webb (Author) - Menzies School of Health Research
L M Ward (Author) - Menzies School of Health Research
M Y Voutsinos (Author) - Menzies School of Health Research
A Tuanyok (Author) - University of Hawaii, United States
M Mayo (Author) - Menzies School of Health Research
M Kaestli (Author) - Menzies School of Health Research
B J Currie (Author) - Menzies School of Health Research
Publication details: PLoS One, Vol.9(3), e91682
Publisher: Public Library of Science
Date published: 2014
DOI: 10.1371/journal.pone.0091682
ISSN: 1932-6203; 1932-6203
Copyright note: Copyright © 2014 Sarovich et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99450578702621
Output Type: Journal article
Research Statement: false

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Web Of Science research areas: Microbiology

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