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Published VersionCC BY V4.0, Open Access
Journal article
Vampire Venom: Vasodilatory Mechanisms of Vampire Bat (Desmodus rotundus) Blood Feeding
Toxins, Vol.11(1), pp.1-10
2019
PMID: 30626071
Abstract
Animals that specialise in blood feeding have particular challenges in obtaining their meal, whereby they impair blood hemostasis by promoting anticoagulation and vasodilation in order to facilitate feeding. These convergent selection pressures have been studied in a number of lineages, ranging from fleas to leeches. However, the vampire bat (Desmondus rotundus) is unstudied in regards to potential vasodilatory mechanisms of their feeding secretions (which are a type of venom). This is despite the intense investigations of their anticoagulant properties which have demonstrated that D. rotundus venom contains strong anticoagulant and proteolytic activities which delay the formation of blood clots and interfere with the blood coagulation cascade. In this study, we identified and tested a compound from D. rotundus venom that is similar in size and amino acid sequence to human calcitonin gene-related peptide (CGRP) which has potent vasodilatory properties. We found that the vampire bat-derived form of CGRP (i.e., vCGRP) selectively caused endothelium-independent relaxation of pre-contracted rat small mesenteric arteries. The vasorelaxant efficacy and potency of vCGRP were similar to that of CGRP, in activating CGRP receptors and Kv channels to relax arteriole smooth muscle, which would facilitate blood meal feeding by promoting continual blood flow. Our results provide, for the first time, a detailed investigation into the identification and function of a vasodilatory peptide found in D. rotundus venom, which provides a basis in understanding the convergent pathways and selectivity of hematophagous venoms. These unique peptides also show excellent drug design and development potential, thus highlighting the social and economic value of venomous animals. Key Contribution: In this study, we identified a compound from D. rotundus venom (vCGRP) that induces vasodilation of resistance vessels such as mesenteric arteries partly via voltage-gated potassium channels and endothelium independent mechanisms. The human form of CGRP is a potent vasodilator that acts partially via endothelium dependent and independent mechanisms.
Details
- Title
- Vampire Venom: Vasodilatory Mechanisms of Vampire Bat (Desmodus rotundus) Blood Feeding
- Authors
- Rahini Kakumanu (Author) - Monash UniversityWayne C Hodgson (Author) - Monash UniversityRavina Ravi (Author) - Monash UniversityAlejandro Alagón (Author) - Universidad Nacional Autónoma de MéxicoRichard Harris (Author) - The University of QueenslandBrust Andreas (Author) - The University of QueenslandPaul F Alewood (Author) - The University of QueenslandBarbara K Kemp-Harper (Author) - Monash UniversityBryan G Fry (Corresponding Author) - The University of Queensland
- Publication details
- Toxins, Vol.11(1), pp.1-10
- Publisher
- MDPI AG
- Date published
- 2019
- DOI
- 10.3390/toxins11010026
- ISSN
- 2072-6651
- PMID
- 30626071
- Copyright note
- © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991177843902621
- Output Type
- Journal article
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- Food Science & Technology
- Toxicology
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