Journal article
Validation study of the accuracy of echocardiographic measurements of systemic blood flow volume in newborn infants
Journal of the American Society of Echocardiography, Vol.26(12), pp.1365-1371
2013
Abstract
Background The echocardiographic assessment of circulatory function in sick newborn infants has the potential to improve patient care. However, measurements are prone to error and have not been sufficiently validated. Phase-contrast magnetic resonance imaging (MRI) provides highly validated measures of blood flow and has recently been applied to the newborn population. The aim of this study was to validate measures of left ventricular output and superior vena caval flow volume in newborn infants. Methods Echocardiographic and MRI assessments were performed within 1 working day of each other in a cohort of newborn infants. Results Examinations were performed in 49 infants with a median corrected gestational age at scan of 34.43 weeks (range, 27.43-40 weeks) and a median weight at scan of 1,880 g (range, 660-3,760 g). Echocardiographic assessment of left ventricular output showed a strong correlation with MRI assessment (R2 = 0.83; mean bias, -9.6 mL/kg/min; limits of agreement, -79.6 to +60.0 mL/kg/min; repeatability index, 28.2%). Echocardiographic assessment of superior vena caval flow showed a poor correlation with MRI assessment (R2 = 0.22; mean bias, -13.7 mL/kg/min; limits of agreement, -89.1 to +61.7 mL/kg/min; repeatability index, 68.0%). Calculating superior vena caval flow volume from an axial area measurement and applying a 50% reduction to stroke distance to compensate for overestimation gave a slightly improved correlation with MRI (R2 = 0.29; mean bias, 2.6 mL/kg/min; limits of agreement, -53.4 to +58.6 mL/kg/min; repeatability index, 54.5%). Conclusions Echocardiographic assessment of left ventricular output appears relatively robust in newborn infant. Echocardiographic assessment of superior vena caval flow is of limited accuracy in this population, casting doubt on the utility of the measurement for diagnostic decision making.
Details
- Title
- Validation study of the accuracy of echocardiographic measurements of systemic blood flow volume in newborn infants
- Authors
- B Ficial (Author) - Imperial College London, United KingdomA E Finnemore (Author) - Imperial College London, United KingdomD J Cox (Author) - Imperial College London, United KingdomKathryn Broadhouse (Author) - Imperial College London, United KingdomA N Price (Author) - Imperial College London, United KingdomG Durighel (Author) - Imperial College London, United KingdomG Ekitzidou (Author) - Imperial College London, United KingdomJ V Hajnal (Author) - Imperial College London, United KingdomA D Edwards (Author) - Imperial College London, United KingdomA M Groves (Author) - Imperial College London, United Kingdom
- Publication details
- Journal of the American Society of Echocardiography, Vol.26(12), pp.1365-1371
- Publisher
- Mosby, Inc.
- Date published
- 2013
- DOI
- 10.1016/j.echo.2013.08.019
- ISSN
- 0894-7317
- Organisation Unit
- School of Science and Engineering - Legacy; School of Health - Nursing; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99451232102621
- Output Type
- Journal article
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- Domestic collaboration
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- Cardiac & Cardiovascular Systems
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