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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men
Papillomavirus Research, Vol.3, pp.80-84
2017
PMID: 28720461
Abstract
Objective
HPV causes ~90% of anal cancer and HPV16 is the type most commonly associated with anal cancer. Gay and bisexual men (GBM) are at greatly increased risk. We investigated patterns of vaccine-preventable anal HPV in older GBM.
Methods
The Study of the Prevention of Anal Cancer (SPANC) is an ongoing, prospective cohort study of HIV-positive and HIV-negative Australian GBM. Participants completed questionnaires and underwent an anal swab for HPV genotyping using Roche Linear Array. We analysed baseline data from SPANC by HPV type, mean number of types, stratified by age and HIV status.
Results
Anal HPV results from 606 (98.2%) of 617 participants (median age 49 years, 35.7% HIV-positive) showed 525 (86.7%) had ≥1 HPV type and 178 (29.4%) had HPV16. Over one third of participants (214, 35.3%) had no nonavalent vaccine-preventable types detected. Two (0.3%) participants had all quadrivalent types and none had all nonavalent vaccine types. HIV-positive participants (p<0.001) and younger participants (p=0.059) were more likely to have more vaccine-preventable HPV types detected.
Conclusion
Anal HPV was highly prevalent in this largely community-based GBM cohort. Vaccine-preventable HPV16 was detected in approximately one third of participants. These findings suggest that the potential efficacy of HPV vaccination of older GBM should be explored.
Details
- Title
- Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men
- Authors
- I Mary Poynten (Corresponding Author) - UNSW SydneySepehr N Tabrizi - The University of MelbourneFengyi Jin - The University of MelbourneDavid J Templeton - Sydney Sexual Health CentreDorothy A Machalek - Royal Women's HospitalAlyssa M Cornall - The University of MelbourneSamuel Phillips - Murdoch Children's Research InstituteChristopher K Fairley - Melbourne Sexual Health CentreSuzanne M Garland - Royal Women's HospitalCarmella Law - St Vincent's Hospital SydneyAndrew Carr - St Vincent's Hospital SydneyRichard J Hillman - Sydney Sexual Health CentreAndrew E Grulich - UNSW Sydney
- Publication details
- Papillomavirus Research, Vol.3, pp.80-84
- Publisher
- Elsevier BV
- Date published
- 2017
- DOI
- 10.1016/j.pvr.2017.02.003
- ISSN
- 2405-8521
- PMID
- 28720461
- Copyright note
- © 2017 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
- Grant note
- This work was supported by the National Health and Medical Research Council Program Grant (Sexually transmitted infections: Causes, consequences and interventions Grant #568971); and a Cancer Council New South Wales Strategic Research Partnership Program Grant (Preventing morbidity and mortality from anal cancer Grant #13–11).
- Organisation Unit
- School of Health - Biomedicine; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991144230702621
- Output Type
- Journal article
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