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Physiological Reports - 2015 - Tran - Uteroplacental insufficiency leads to hypertension but not glucose intolerance or653.92 kB
Published VersionCC BY V4.0, Open Access
Published VersionCC BY V4.0, Open
Journal article
Uteroplacental insufficiency leads to hypertension, but not glucose intolerance or impaired skeletal muscle mitochondrial biogenesis, in 12-month-old rats
Physiological Reports, Vol.3(9), pp.1-16
2015
PMID: 26416974
Abstract
Growth restriction impacts on offspring development and increases their risk of disease in adulthood which is exacerbated with "second hits." The aim of this study was to investigate if blood pressure, glucose tolerance, and skeletal muscle mitochondrial biogenesis were altered in 12-month-old male and female offspring with prenatal or postnatal growth restriction. Bilateral uterine vessel ligation induced uteroplacental insufficiency and growth restriction in offspring (Restricted). A sham surgery was also performed during pregnancy (Control) and some litters from sham mothers had their litter size reduced (Reduced litter), which restricted postnatal growth. Growth-restricted females only developed hypertension at 12 months, which was not observed in males. In Restricted females only homeostasis model assessment for insulin resistance was decreased, indicating enhanced hepatic insulin sensitivity, which was not observed in males. Plasma leptin was increased only in the Reduced males at 12 months compared to Control and Restricted males, which was not observed in females. Compared to Controls, leptin, ghrelin, and adiponectin were unaltered in the Restricted males and females, suggesting that at 12 months of age the reduction in body weight in the Restricted offspring is not a consequence of circulating adipokines. Skeletal muscle PGC-1 alpha levels were unaltered in 12-month-old male and female rats, which indicate improvements in lean muscle mass by 12 months of age. In summary, sex strongly impacts the cardiometabolic effects of growth restriction in 12-month-old rats and it is females who are at particular risk of developing longterm hypertension following growth restriction.
Details
- Title
- Uteroplacental insufficiency leads to hypertension, but not glucose intolerance or impaired skeletal muscle mitochondrial biogenesis, in 12-month-old rats
- Authors
- Melanie Tran (Author) - The University of MelbourneMargaret E. Young (Author) - The University of MelbourneAndrew J. Jefferies (Author) - The University of MelbourneDeanne H. Hryciw (Author) - The University of MelbourneMichelle M. Ward (Author) - The University of MelbourneErica L. Fletcher (Author) - The University of MelbourneMary E. Wlodek (Corresponding Author) - The University of MelbourneGlenn D. Wadley (Author) - Deakin University
- Publication details
- Physiological Reports, Vol.3(9), pp.1-16
- Publisher
- John Wiley & Sons Ltd.
- Date published
- 2015
- DOI
- 10.14814/phy2.12556
- ISSN
- 2051-817X
- PMID
- 26416974
- Copyright note
- © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Grant note
- National Health and Medical Research Council of Australia
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991186519802621
- Output Type
- Journal article
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