Journal article
Usefulness of myocardial contrast echocardiography using low-power continuous imaging early after acute myocardial infarction to predict late functional left ventricular recovery
American Journal of Cardiology, Vol.92(5), pp.493-497
2003
Abstract
Microvascular perfusion is a prerequisite for ensuring viability early after acute myocardial infarction (AMI). For adequate assessment of myocardial perfusion, both myocardial blood volume and velocity need to be evaluated. Due to its high frame rate, low-power continuous myocardial contrast echocardiography (MCE) can rapidly assess these parameters of myocardial perfusion. We hypothesized that the technique can accurately differentiate necrotic from viable myocardium after reperfusion therapy in AMI. Accordingly, 50 patients underwent low-power continuous MCE using intravenous Optison (Amersham Health, Amersham, Middlesex, United Kingdom) 7 to 10 days after AMI. Myocardial perfusion (contrast opacification assessed over 15 cardiac cycles after the destruction of microbubbles with high energy pulses) and wall thickening were assessed at baseline. Regional and global left ventricular (LV) function was reassessed after 12 weeks. Out of the 297 dysfunctional segments, MCE detected no contrast enhancement during 15 cardiac cycles in 172 segments, of which 160 (93%) failed to show improvement. MCE demonstrated contrast opacification during 15 cardiac cycles in 77 segments, of which 65 (84%) showed recovery of function. The greater the extent and intensity of contrast opacification, the better the LV function at 3 months (p <0.001, r = -0.91). Almost all patients (94%) with <20% perfusion in dysfunctional myocardium (assessing various cut-offs) failed to demonstrate an improvement in LV function. MCE and peak creatine kinase proved to be independent predictors of functional recovery (p ?<0.001). In conclusion, low-power continuous MCE is an accurate and rapid bedside technique to identify microvascular perfusion after AMI. This technique may be utilized to reliably predict late recovery of function in dysfunctional myocardium after AMI. © 2003 by Excerpta Medica, Inc.
Details
- Title
- Usefulness of myocardial contrast echocardiography using low-power continuous imaging early after acute myocardial infarction to predict late functional left ventricular recovery
- Authors
- R Janardhanan (Author) - Department of Cardiovascular Medicine, United KingdomJ M A Swinburn (Author) - Department of Cardiovascular Medicine, United KingdomKim Greaves (Author) - Department of Cardiovascular Medicine, United KingdomR Senior (Author) - Department of Cardiovascular Medicine, United Kingdom
- Publication details
- American Journal of Cardiology, Vol.92(5), pp.493-497
- Publisher
- Elsevier Inc.
- Date published
- 2003
- DOI
- 10.1016/S0002-9149(03)00713-6
- ISSN
- 0002-9149
- Organisation Unit
- Faculty of Science, Health, Education and Engineering; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99450092102621
- Output Type
- Journal article
Metrics
369 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web Of Science research areas
- Cardiac & Cardiovascular Systems
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites